Long-term Sequelae of Childhood Meningitis and Meningococcal Purpura Fulminans

Centre Hospitalier Intercommunal Creteil43 enrolled

Overview

While the initial evolution of meningococcal meningitis (MM) is well described, there are few data on the long-term evolution, beyond 1 year. The objective of this research is to evaluate the sequelae of MM beyond 1 year in patients with a history of MM followed in Paris area, France. Most children with MM in France have been included in the MM register and are still being followed. Parents will be offered a detailed clinical evaluation of their child including: a clinical and neurological examination, a cognitive performance assessment, an auditory, speech and visual assessment and an evaluation of the child's progress at school.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Meningitis, Meningococcal Sequela

Interventions

sequela evaluationOTHER

clinical and neurological examination, psychological evaluation (cognitive performance), an auditory, speech and visual assessment and an evaluation of the child's school performance

Eligibility

Sex: ALLMax age: 17 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Infants and children from 0 to 17 years old * Having had meningitis or meningococcal purpura fulminans between 2010 and 2021 * Delay ≥ 1 year between the date of diagnosis of meningitis or purpura meningococcal fulminans and the date of inclusion in the study (signature of the informed consent) * The holders of parental authority have read and understood the information letter and their express consent has been obtained * Patient affiliated to a social security system (Social Security or Universal Medical Coverage) Exclusion Criteria: * refusal to participate

Locations (9)

CHU Bicêtre

Le Kremlin-Bicêtre, Kremlin Bicêtre, France

CHU Annecy

Annecy, France

CHI créteil

Créteil, France

Centre Intercommunal de Villeneuve Saint Georges

Crosne, France

Groupe Hospitalier Nord Essonne

Longjumeau, France

GHEF site de Meaux

Meaux, France

Hôpital Necker Enfants Malades

Paris, France

Robert debré hospital

Paris, France

Ch Pontoise

Pontoise, France

Outcomes

Primary Outcomes

Number of children with at least one neurological, orthopedic or sensory sequelae

Time frame: 1 year

Secondary Outcomes

Number of children with severe neurological sequelae

Time frame: 1 year

Number of children with orthopedic complications

Time frame: 1 year

Number of children with sensory disorders

Time frame: 1 year

Number of children with skin sequelae

Time frame: 1 year

Number of children with learning disabilities

Time frame: 1 year

Number of children with cognitive or psychological difficulties identified on the WPPSI, WISC V or VINELAND depending on their age and capacity

95% of the population has a Total IQ between 70 and 130 (from low intelligence to high intelligence).

Time frame: 1 year

Number of consultations during follow-up

Time frame: 1 year

Post-traumatic stress in parents using the IES-R questionnaire

A score up to 33 is associated with a stress post traumatic

Time frame: 1 year