Long-term Effects of COVID-19 in Adolescents

University Hospital, Akershus516 enrolled

Overview

The overarching objective for this prospective cohort study of COVID-19 in adolescents is to study the long-term effects, with particular emphasis on post-infectious chronic fatigue. A total of 500 individuals with a SARS-CoV-2 positive test will be enrolled in the acute phase of COVID-19 and followed for 6 months. A total of 100 individuals with SARS-CoV-2 negative test will be included during the same time period as a control group. Investigations include autonomic, pulmonary and cognitive assessement; a questionnaire charting symptoms, emotionality, personality, loneliness, life events and demographics; and extensive biobanking including genetic markers, viable PBMC, urine, feces and hair. A subgroup of 40 SARS-CoV-2 positive and 20 SARS-CoV-2 negative individuals will also undergo detailed cardiological examination by echocardiography. Primary endpoints are fatigue at 6 months as assessed by the Chalder Fatigue Scale and post-COVID-19 syndrome cases at 6 months according to the WHO definition

Study Type

OBSERVATIONAL

Enrollment

516

Conditions

Covid19

Interventions

No active intervention (observational only)OTHER

Eligibility

Sex: ALLMin age: 12 YearsMax age: 25 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Positive SARS-CoV-2 test/negative SARS-CoV-2 test * Age 12 - 25 years * Living in the counties of Oslo or Viken, Norway * \< 28 days since onset of first symptom Exclusion Criteria: * Hospitalised due to COVID-19 * Pregnancy * Lack of consent

Outcomes

Primary Outcomes

Fatigue

Total sum score on the Chalder Fatigue Scale (range 0 - 33, lower scores means less fatigue, ie. better outcome)

Time frame: 6 months follow-up

Post-COVID-19 syndrome caseness

Post-COVID-19 syndrome casesness according to the WHO definition (issued Sept. 2021; hence, this endpoint was added during the course of the study, but prior to database lock.)