Precise description of behavioral signs denoting transition from unresponsive wakefulness syndrome/vegetative state (UWS/VS) to minimally conscious state (MCS) or emergence from MCS after severe brain injury is crucial for prognostic purposes. A few studies have attempted this goal but involved either non-standardized instruments, limited temporal accuracy or samples, or focused on (sub)acute patients. The objective of this study is to describe the behavioral signs that led to a change of diagnosis, as well as the factors influencing this transition, in a large sample of patients with chronic disorders of consciousness after severe brain injury.
Study Type
OBSERVATIONAL
Enrollment
100
Multidisciplinary rehabilitation
Servicio de Neurorrehabilitación y Daño Cerebral de los Hospitales NISA
Valencia, Spain
Change from baseline score in the Coma Recovery Scale-Revised until study completion
The Coma Recovery Scale-Revised consists of 29 hierarchically organised items divided into 6 subscales addressing auditory, visual, motor, oromotor, communication, and arousal processes.
Time frame: From inclusion in the study until discharge or death, assessed up to 24 months
Change from baseline score in the Functional Independence Measure until study completion
The Functional Independence Measure is an 18-item measurement tool that explores an individual's physical, psychological and social function
Time frame: From inclusion in the study until discharge or death, assessed up to 24 months
Change from baseline score in the Disability Rating Scale until study completion
The Disability Rating Scale is an 8-item measure that assesses disability of individuals with moderate to severe traumatic brain injury at a wide range of functional levels from coma through community living
Time frame: rom inclusion in the study until discharge or death, assessed up to 24 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.