Umbilical cord blood mononuclear cells (MNC) may improve the wound repair ability. This study aims to investigate the role of MNC in refractory diabetic foot ulcer by comparing the combination of PRP and MNC with PRP alone.
The difficulty in the healing of diabetic foot is related to the loss of local repair microenvironment. The platelet rich plasma (PRP) can improve the repair ability, however, the requirement for wound bed preparation is strict, or treatment failure may occur. Umbilical cord blood mononuclear cells (MNC) may provide a better repair environment through paracrine action. This study aims to investigate the role of MNC in refractory diabetic foot ulcer by comparing the combination of PRP and MNC with PRP alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
40
Local wound treatment by combination of PRP and MNC, once;
Local wound treatment by PRP alone, once.
Peking University Third Hospital
Beijing, Beijing Municipality, China
RECRUITINGWound area reduction rate
The ratio of the reduced area after one week of treatment to the original area
Time frame: one week
Wound healing rate at 4 weeks
Percentage of patients with healed wound at 4 weeks
Time frame: 4 weeks
Amputation rate at 8 weeks
Percentage of patients with major amputation at 8 weeks
Time frame: 8 weeks
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