This open label, prospective observational, single-center registry is to study short-, intermediate-and long-term course of postpartum hypertension and predictors/risk factors associated with long term cardiovascular and renal risk. Current disease management strategies will be evaluated.
Study Type
OBSERVATIONAL
Enrollment
480
Blood results will be taken out of next routine venipuncture. Routinely collected standard parameters are a blood count, chemistry panel including renal parameters and electrolytes, lipid profile and a HbA1c as well as albumin/creatinine and protein/creatinine ratio in urine.
Clinic blood pressure and 24hour BP Measurements
Subjects participating in home-based blood pressure management via telemonitoring will receive a free HekaHealth application (App) for the structured assessment of HBPM.
Medical Outpatient Department and Hypertension Clinic, University Hospital Basel
Basel, Switzerland
RECRUITINGFrequency of persistent hypertension defined by 24 hours BP measurement
Frequency of persistent hypertension defined by 24 hours BP measurement
Time frame: through study completion, an average of 5 years
Frequency of persistent hypertension defined by office blood pressure measurement (OBPM, AOBPM)
Frequency of persistent hypertension defined by office blood pressure measurement (OBPM, AOBPM)
Time frame: through study completion, an average of 5 years
Frequency of microalbuminuria
Frequency of microalbuminuria
Time frame: through study completion, an average of 5 years
Frequency of damage to the retina of the eyes (retinopathy)
Frequency of damage to the retina of the eyes (retinopathy)
Time frame: through study completion, an average of 5 years
Signs of hypertensive heart disease
Signs of hypertensive heart disease at transthoracic echocardiography determined by left ventricular hypertrophy (LVH)
Time frame: up to 24 months
Frequency of dyslipidemia
Frequency of dyslipidemia
Time frame: through study completion, an average of 5 years
Frequency of prediabetes/diabetes
Frequency of prediabetes/diabetes
Time frame: through study completion, an average of 5 years
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Substudy where possible cardiac, renal and pregnancy related biomarkers will be additionally analyzed. The following biomarkers will be analyzed: N terminal (NT)-proBNP, Troponin, elevated mid-regional pro-atrial natriuretic peptide (ANP), elevated mid-regional pro adrenomedullin (ADM), soluble fms-like tyrosine kinase (sFlt-1), and placenta growth factor (PlGF).
Data collection on patient reported outcomes (Questionnaire EQ-5D, Questionnaire for App based monitoring )