CAR-T for r/r Malignant Tumors in Children

Inclusion Criteria: * Age 3-18 * Expected survival time ≥ 12weeks * ECOG 0-2 * At least second-line or above chemotherapy failed * Liver and kidney function, heart and lung function meet the following requirements: Creatinine is within the normal range; Left ventricular ejection fraction ≥ 45%; Baseline blood oxygen saturation\>91%; Total bilirubin≤1.5×ULN; ALT and AST≤2.5×ULN * Understand the trial and have signed the informed consent Exclusion Criteria: * Those who have graft-versus-host disease (GVHD) or need to use immunosuppressive agents * Hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) positive and peripheral blood HBV DNA titer test is not within the normal reference range; hepatitis C virus (HCV) antibody positive and peripheral blood HCV RNA positive; human immunodeficiency virus (HIV) Antibody positive; CMV DNA test positive; Syphilis test positive * Severe heart disease * Systemic diseases judged by the investigator to be unstable: including but not limited to severe liver, kidney or metabolic diseases that require medication * Within 7 days before screening, there are active infections or uncontrollable infections that require systemic treatment (except for mild urogenital infections and upper respiratory tract infections) * Those who have received CAR-T therapy or other genetically modified cell therapy before screening * According to the researcher's judgment, it does not meet the situation of cell preparation * Situations that other researchers think are not suitable for inclusion