In this study, it is evaluated the effects of laser assisted new attachment procedure (LANAP) and low level laser therapy (LLLT) and on clinical, biochemical and radiographic parameters in addition to non-surgical periodontal treatment (NSPT).
The study was designed as a randomized-controlled, single-blind and parallel design consisting of 80 patients with chronic periodontitis. Study consists of 4 groups, with 20 patients in each group. Group 1 received only NSPT, Group 2 received NSPT+LANAP, Group 3 received NSPT+LLLT, and Group 4 received NSPT+LANAP+LLLT. Clinical measurements of patients and gingival crevicular fluid (GCF) were taken before treatment and after 1 and 3 months. In GCF, interleukin-1beta, interleukin-10 and vascular endothelial growth factor were analyzed. Standard periapical radiographs were taken for radiographic measurements. In moderate (4-6 mm) and deep pockets (7 mm and above), it was found that all groups treated with laser significantly decrease pocket depth (PD) and clinic attachment level (CAL) compared to Group 1. Group 3 caused significantly less gingival recession than all other groups. There was no statistical difference between the groups in biochemical markers. Radiographic analysis revealed that only Group 2 achieved significant bone filling compared to Group 1. Bot LANAP and LLLT application in the deep pockets provide an additional contribution to NSPT. It has been found that LLLT administration leads to decrease in PD by creating a minimum recession.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
89
For LANAP, the fiber optic tip of the Nd:YAG laser (1064 nm) (Fotona Fidelis AT, USA) was used. For LLLT R24 biostimulation handpiece tip (950-μm) Nd:YAG laser (1064 nm) was used.
Katip Celebi University
Izmir, Turkey (Türkiye)
Clinical attachment level gain
The clinical attachment level is determined by measuring the distance from the cemento-enamel junction to the gingival margin and adding the pocket depth to it.
Time frame: Baseline
Clinical attachment level gain
The clinical attachment level is determined by measuring the distance from the cemento-enamel junction to the gingival margin and adding the pocket depth to it.
Time frame: 1 month
Clinical attachment level gain
The clinical attachment level is determined by measuring the distance from the cemento-enamel junction to the gingival margin and adding the pocket depth to it.
Time frame: 3 month
Probing depth
It is determined by measuring the distance from the gingival margin to the pocket base
Time frame: Baseline
Probing depth
It is determined by measuring the distance from the gingival margin to the pocket base
Time frame: 1 Month
Probing depth
It is determined by measuring the distance from the gingival margin to the pocket base
Time frame: 3 Month
Gingival index
For assessing severity of gingivitis, and its location by examining qualitative changes of gingival tissues
Time frame: Baseline
Gingival index
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For assessing severity of gingivitis, and its location by examining qualitative changes of gingival tissues
Time frame: 1 Month
Gingival index
For assessing severity of gingivitis, and its location by examining qualitative changes of gingival tissues
Time frame: 3 Month
Plaque index
This index measures the thickness of plaque on gingival one third
Time frame: Baseline
Plaque index
This index measures the thickness of plaque on gingival one third
Time frame: 1 Month
Plaque index
This index measures the thickness of plaque on gingival one third
Time frame: 3 Month
Bleeding on probing
In this index, probing is performed by gently walking around the pocket and bleeding is evaluated. As a result of probing, evaluation is made by looking at the presence or absence of bleeding in the gingiva.
Time frame: Baseline
Bleeding on probing
In this index, probing is performed by gently walking around the pocket and bleeding is evaluated. As a result of probing, evaluation is made by looking at the presence or absence of bleeding in the gingiva.
Time frame: 1 Month
Bleeding on probing
In this index, probing is performed by gently walking around the pocket and bleeding is evaluated. As a result of probing, evaluation is made by looking at the presence or absence of bleeding in the gingiva.
Time frame: 3 Month
Interleukin-1beta
IL-1 is a protein produced mainly by monocytes and macrophages as a polyclonal activator.
Time frame: Baseline
Interleukin-1beta
IL-1 is a protein produced mainly by monocytes and macrophages as a polyclonal activator.
Time frame: 1 Month
Interleukin-1beta
IL-1 is a protein produced mainly by monocytes and macrophages as a polyclonal activator.
Time frame: 3 Month
Interleukin-10
IL-10 is an 18 kilodalton (KD) cytokine with a wide variety of (pleiotropic) effects.
Time frame: Baseline
Interleukin-10
IL-10 is an 18 kilodalton (KD) cytokine with a wide variety of (pleiotropic) effects.
Time frame: 1 Month
Interleukin-10
IL-10 is an 18 kilodalton (KD) cytokine with a wide variety of (pleiotropic) effects.
Time frame: 3 Month
vascular endothelial growth factor (VEGF)
VEGF is a glycoprotein molecule that is a potential stimulator of angiogenesis.
Time frame: Baseline
vascular endothelial growth factor (VEGF)
VEGF is a glycoprotein molecule that is a potential stimulator of angiogenesis.
Time frame: 1 Month
vascular endothelial growth factor (VEGF)
VEGF is a glycoprotein molecule that is a potential stimulator of angiogenesis.
Time frame: 3 Month
Radiographic bone fill
The effects of treatments on bone loss were evaluated by making some measurements on periapical radiography.
Time frame: Baseline
Radiographic bone fill
The effects of treatments on bone loss were evaluated by making some measurements on periapical radiography.
Time frame: 1 Month
Radiographic bone fill
The effects of treatments on bone loss were evaluated by making some measurements on periapical radiography.
Time frame: 3 Month