A Multi-center Study to Determine the Prevalence and Influence of Pertussis on Subacute Cough in Shenzhen

Shenzhen People's Hospital500 enrolled

Overview

A prospective, multi-center, observational clinical trail. Aim to evaluate the real incidence of COPD pertussis and the impact of pertussis on subaute cough.

1. Investigate the incidence and epidemiological characteristics of pertussis infection in subaute cough population. 2. To explore the relationship between pertussis infection and subaute cough.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Pertussis Chronic Cough

Interventions

Blood samplePROCEDURE

2 ml venous blood was collected and separated into serum.

Data collectionPROCEDURE

1. Whether the patient has been vaccinated with DPT vaccine and record the time of vaccination; 2. Medication situation of patients in the past year, including rescue drugs, antitussive and expectorant drugs, inhaled corticosteroids and antibiotics;

Throat swabPROCEDURE

Before the collection of oropharyngeal swabs, instruct the patient to wash the mouth or gargle, fix the patient's head, open the mouth and expose the throat. If necessary, use a tongue depressor to gently press the tongue. Use the swab to wipe the secretion on both sides of the palatal arch, pharynx and tonsil with a sensitive and gentle action, and quickly withdraw the swab to avoid contacting other parts of the mouth. Put the swab in the sterile test tube, plug the opening with cotton ball, and send it for inspection and registration in time.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The cough lasts 3 to 8 weeks and there is no obvious evidence of lung disease on chest X-ray. Exclusion Criteria: * 1\. Major diseases except subaute cough; 2. Significant abnormality in laboratory examination; 3. Clinical diagnosis of lung cancer, bronchiectasis, pneumoconiosis or other simple restrictive ventilation dysfunction; 4. Patients with a history of asthma, allergic rhinitis, or a blood eosinophil count of 2600/mm3 (0.6x10\^9/L) within 4 weeks; 5. Currently suffering from active tuberculosis; 6. Patients with life-threatening pulmonary embolism, or al-antitrypsin deficiency, or cystic fibrosis; 7. Patients who have undergone lung resection.

Locations (26)

Fuyong people's Hospital of Baoan District, Shenzhen

Shenzhen, China

Outcomes

Primary Outcomes

Evaluation of the prevalence of pertussis among subacute cough

According to the positive rate of bordetella pertussis nucleic acid, evaluate the prevalence of pertussis in subaute cough.