Lanreotide Autogel® has been established as a standard of care for patients with locally advanced or metastatic GEP-NETs based on the success of CLARINET trial. However, only few patients with Asian ethnicity were included in the trial. According to the nationwide comprehensive study of patients with GEP-NET in Korea, hindgut primary NETs(Rectal) occured more frequently than western countries. However, small intestine or lung primary NET is relatively rare compared with western countries.1) Considering the clinical characteristics of GEP-NETs are distinct between the patients in Asian and Western countries, further evaluation on the efficacy and safety of Lanreotide Autogel® in Asian patients with GEP-NETs is needed.
Study Type
OBSERVATIONAL
Enrollment
71
Lanreotide autogel 90-120 mcg, every 4 weeks
Changhoon Yoo
Seoul, Seoul, South Korea
Progression-free survival rate at 2 years
Proportion of patients without tumor progression defined by RECIST version 1.1 at 2 years
Time frame: 2 years
Progression-free survival
Time between lanreotide treatment initiation and disease progression or death
Time frame: 2 years
Response rates
Proportion of patients with tumor response by RECIST version 1.1
Time frame: 2 years
Disease control rates
Proportion of patients with tumor response and stable disease by RECIST version 1.1
Time frame: 2 years
Overall survival
Time between lanreotide treatment initiation and death due to any cause
Time frame: 2 years
Chromogranin A response
Change of serum chromogranin A levels during lanreotide treatment
Time frame: 2 years
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