Tolerability and Efficacy of INSTYLAN in Subjects With Moderate to Severe Hemorrhagic Cystitis

Inclusion Criteria: * Males and females, at least 18 years, * Patients who provided signed written informed consent, which includes compliance with requirements listed in the consent form, * Patients with diagnosis of Hemorrhagic Cystitis, * Patients with diagnosis of bladder pain (pressure or pelvic discomfort) with at least one other urinary symptom (need to urinate right away (urgency), often (frequency), or both). Exclusion Criteria: * Patients with Post-void residual (PVR) urine volume \> 200ml, * Patients presently treated with intravesical treatment (replenishment therapy with glycosaminoglycans), * Patients receiving HyperBaric Oxygen Therapy (HBOT), * Patients with neurogenic bladder, * Patients treated with neuromodulation techniques within the last six months, * Patients undergoing or scheduled for radiation therapy, brachytherapy, chemotherapy or treatment with BCG or with Mitomycin-C, * Patients suffering from lower urinary infections (UTIs), * Patients with unstable cardiovascular disease, * Patients with any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial.