This trial will evaluate the effect of prescribed exercise training on quality of life and exercise capacity of patients with advanced heart failure or after ventricular assist device implantation. Furthermore, clinical, laboratory and echocardiographic markers of heart failure, rehospitalization rates and cost-effectiveness will be assessed.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
14
exercise training in an approved rehabilitation program
German Heart Institute
Berlin, Germany
RECRUITINGEfficacy of exercise training in severe heart failure as assessed by quality of life
Change of quality of life by Kansas City Cardiomyopathy Questionnaire
Time frame: after 3, 6 and 12 months
Efficacy of exercise training in severe heart failure as assessed by exercise capacity
Change of exercise capacity measured by six-minute walking distance in meters
Time frame: after 3, 6 and 12 months
rehospitalization rates
Change in rehospitalization rate or unplanned outpatient healthcare visits due to symptoms of heart failure measured by a final visit and record screening
Time frame: 12 months before training and 12 months while training
heart failure biomarkers
Change in biomarkers of heart failure: NTproBNP
Time frame: after 6 and 12 months
Renal function biomarker: Creatinin
Change in biomarkers of renal function: creatinin
Time frame: after 6 and 12 months
Renal function biomarkers: glomerular Filtration rate
Change in biomarkers of renal function: glomerular filtration rate
Time frame: after 6 and 12 months
Hepatic function biomarkers: transaminases
Change in biomarkers of hepatic function: transaminases
Time frame: after 6 and 12 months
Hepatic function biomarkers: gamma-glutamyltransferase
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Change in biomarkers of hepatic function: gamma-glutamyltransferase
Time frame: after 6 and 12 months
Heart failure Progression: Ejection fractions
Change of echocardiographic findings: ejection fraction (in %)
Time frame: after 6 and 12 months
Heart failure Progression: Diameters
Change of echocardiographic findings: diameters (in mm)
Time frame: after 6 and 12 months
Heart failure Progression: Aortic Valve opening
Change of echocardiographic findings: aortic valve opening
Time frame: after 6 and 12 months
Heart failure Progression: Valvular regurgitations
Change of echocardiographic findings: Valvular regurgitation (in grades I-III°)
Time frame: after 6 and 12 months