Perioperative neurocognitive disorders(PND) is common to see in elderly patients. Although PND increases patient mortality as well as hospitalization time, apparent inflammatory factors, and related mechanisms are still unknown. Metabolites could reveal chemical fingerprints left behind by cellular processes, which in turn provide a new aspect to understand the biological process behind. we aim to found the metabolomics can aid the development of diagnostic markers of PND screening, early detection, and further, provide a basis for disease prevention and treatment.
Study Type
OBSERVATIONAL
Enrollment
300
Changhai Hospital, Second Military Medical University
Shanghai, Shanghai Municipality, China
RECRUITINGthe level of metabolomics in patients' blood sample
Time frame: baseline
the level of metabolomics in patients' blood sample
Time frame: 24 hours after operation
the level of metabolomics in patients' blood sample
Time frame: 72 hours after operation
CAM-ICU score
Time frame: baseline
CAM-ICU score
Time frame: 24 hours after operation
CAM-ICU score
Time frame: 72 hours after operation
CAM-ICU score
Time frame: 1 month after operation
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