This study is designed to test the effects of the combination of naringenin (from an extract of sweet oranges) and beta carotene on energy expenditure and glucose metabolism in a single human subject.
The subject will be treated for 8 weeks with the combination of naringenin + beta carotene. We will conduct the following assessments before the treatment and at the end of eight weeks. 1. Resting metabolic rate 2. Oral glucose tolerance test with glucose and insulin 3. Ambulatory blood pressure 4. Recording of adverse events 5. Body weight
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
1
Subject will ingest 300 mg naringenin three times/day and 6 mg beta carotene two times/day for eight weeks
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States
Energy expenditure
Ventilated hood
Time frame: Five hours
Incidence of Treatment-Emergent Adverse Events
Adverse events
Time frame: Eight weeks
Glucose metabolism
Oral glucose tolerance test with insulin
Time frame: Three hours
Blood pressure
Ambulatory
Time frame: 24 hours
Body weight
Measurement of body weight
Time frame: 16 weeks
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