This is a single-center, non-randomzied pilot study investigating a combination of targeted therapies as possible treatment for heart failure with preserved ejection fraction (HFpEF). The study interviention is a Low-Dose, Triple Polydiuretic Therapy (LDTPT, or polydiuretic) including loop diuretic (bumetanide), mineralocorticoid receptor antagonist (eplerenone), and Sodium-glucose co-transporter 2 inhibitors (SGLT2i) therapy (dapaglifozin).
Patients with HFpEF and diabetes mellitus will receive polydiuretic therapy consisting of bumetanide 0.5 mg + eplerenone 25 mg + dapaglifozin 5 mg on top of background therapy. These medicines are currently FDA approved and recommended by clinical practice guidelines for the treatment of HFpEF (bumetanide, eplerenone) and diabetes mellitus (dapaglifozin). This study is designed to evaluate if combination pharmacotherapies with synergistic or additive diuretic properties can improve adherence, treatment efficacy, and effectiveness with fewer side effects
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Low-Dose, Triple Polydiuretic Therapy (LDTPT) Treatment consists of: * Loop diuretic (bumetanide 0.5 mg) * Mineralocorticoid receptor antagonist (eplerenone 25 mg) * Sodium-glucose co-transporter 2 inhibitor (SGLT2i): Farxiga® (dapagliflozin) 5 mg
Northwestern University
Chicago, Illinois, United States
Change in NT-proBNP
Change in NT-proBNP after 4 weeks of treatment
Time frame: 4 weeks
Change in Systolic and Diastolic Blood pressure
Change in blood pressure after 4 weeks of treatment
Time frame: 4 weeks
Change in body weight
Change in weight after 4 weeks of treatment
Time frame: 4 weeks
Compliance
Overall compliance with polydiuretic as assessed by pill count
Time frame: 4 weeks
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