Ultrasound-guided Regional Anesthesia vs Local Infiltration Anesthesia With Dexmedetomidine and Ropivacaine

Medical University of Graz50 enrolled

Overview

Evaluation of the Impact of dexmedetomidine as an adjunct for local infiltrations analgesia and ultrasound-based regional anaesthesia as pain medication in regard to patients' opioid need the first 48 hours after the total knee replacement operation. Secondary objectives are: Pain assesment, Pain medication necessary, functionality of the prothesis, satisfaction, wellbeing, postoperative discomforts, complications (delirium, allergic reactions, cardiopulmonary decompensation), procedure specific time.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pain, Postoperative Anesthesia, Local Gonarthrosis

Interventions

Ultrasound guided regional anesthesiaDRUG

Applied perineurally preoperatively ultrasound guided regional anesthesia

Local infiltration analgesiaDRUG

Applied in the wound intraoperatively from the orthopedics

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult * non pregnant * patients with gonarthrosis who have given written consent for participation Exclusion Criteria: * Age below 18 years * pregnancy * breast-feeding patients * allergies against study medication * missing or denied written consent

Locations (1)

Medical University Hospital LKH Graz

Graz, Austria

Outcomes

Primary Outcomes

Need of opioid consumption in oral morphine equivalent

consumed opioids in mg of oral morphine equivalent

Time frame: 48 hours postoperatively

Secondary Outcomes

Pain assesment

Pain experienced by patients according to self-assesment according to NRS (Numeric rating scale) (minimum 0, maximum 10) (higher score means worse outcome)