Endostar Combined With AI Regimen Compared With AI in Adjuvant Treatment

Inclusion Criteria: 1. Patients with soft tissue sarcoma confirmed by histopathology and cytology; 2. Patients with soft tissue sarcoma judged to be stage IIB/III according to the AJCC staging of soft tissue sarcoma; 3. Patients who have previously undergone surgery can be included in the group, but according to the researcher's evaluation, they must have recovered and the operation completion time is at least 4 weeks from the study entry; 4. Local radiotherapy can be received during chemotherapy; 5. Have received anti-tumor drug treatment in the past, including adjuvant or neoadjuvant chemotherapy, but it has been over 6 months before the start of the study treatment; 6. R0 resection after local recurrence, non-chemotherapeutic resistant soft tissue sarcoma, including synovial sarcoma, pleomorphic liposarcoma, myxoid/round cell liposarcoma, pleomorphic undifferentiated sarcoma, leiomyosarcoma, myxofibrosarcoma, Angiosarcoma, malignant peripheral nerve sheath tumor, epithelioid sarcoma, etc., except Ewing's sarcoma, embryonic/acinoid rhabdomyosarcoma and other sarcomas that do not use AI regimen as the first-line chemotherapy regimen, and some chemotherapy-insensitive sarcomas: highly differentiated/removed Differentiated liposarcoma, clear cell sarcoma, alveolar soft tissue sarcoma, extraosseous mucinous chondrosarcoma, etc.; 7. No gender limit, ≥18 years old; 8. ECOG score ≤ 2; 9. The expected survival period is ≥3 months; 10. Sufficient blood function: absolute neutrophil count (ANC)≥1.5×109/L and platelet count≥80×109/L and hemoglobin≥9 g/dL; 11. Sufficient liver function: total bilirubin ≤ upper limit of normal (ULN); AST and ALT ≤ 1.5 times upper limit of normal (ULN); alkaline phosphatase ≤ 5 times upper limit of normal (ULN); 12. Sufficient renal function: serum creatinine ≤ upper limit of normal (ULN) or calculated creatinine clearance ≥ 60 mL/min; 13. The electrocardiogram is basically normal, and there is no unhealed wound on the body; 14. Those who have not had a severe allergic reaction to biological agents, especially E. coli genetic engineering products; 15. Women of childbearing age must agree to use contraceptive measures (such as intrauterine device (IUD), contraceptives or condoms) during the study period and within 6 months after the end of the study; serum or urine pregnancy within 7 days before study entry The test is negative and must be a non-lactating patient; men should agree to use contraception during the study period and within 6 months after the end of the study period. 16. The patient voluntarily joined the study, signed an informed consent form, had good compliance, and was able to be followed up by the trial staff. Exclusion Criteria: 1. Pregnant or lactating women, or female patients who are fertile but have not taken contraceptive measures; 2. There are severe acute infections that have not been controlled; or there are purulent and chronic infections, and the wounds do not heal; 3. There is a second primary tumor (except skin basal cell carcinoma); 4. Those who have participated in other drug clinical trials within 4 weeks. 5. Pre-existing severe heart disease, including: congestive heart failure, uncontrollable high-risk arrhythmia, unstable angina, myocardial infarction, severe heart valve disease, and refractory hypertension; 6. People with uncontrollable neurological or mental illnesses or mental disorders, poor compliance, and unable to cooperate and describe the treatment response; primary brain tumors or central nerve metastases have not been controlled, and have obvious intracranial hypertension or neuropsychiatry Symptoms; 7. Those with bleeding tendency; 8. Evidence of hereditary hemorrhagic constitution or coagulopathy; 9. A clear history of allergy to chemotherapy drugs