Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)

Inclusion Criteria: * (1) Patients with aortic dissection/ulceration/intermural hematoma/aortic aneurysm who underwent aortic arch replacement or endoluminal isolation or hybrid therapy; * (2) Paitents without clinically significant hyperlipidemia but with cardiovascular disease risk factors (such as male ≥45 years old, female ≥55 years old, hypertension, diabetes, chronic kidney disease, obesity, low HDL cholesterol, smoking, alcohol consumption, family history of early onset ischemic cardiovascular disease) and no previous use of statins; * (3) Patients are between 18 and 85 years old, male or female; * (4) Agree to participate in the study and sign the informed consent. Exclusion Criteria: * (1) Patients with allergy to statins; * (2) patients with active liver disease; * (3) patients with myopathy; * (4) Lactating women and pregnant women; * (5) Patients with mental diseases, drug and alcohol dependence; * (6) Refuse to participate in the study or sign the informed consent.