The Effects of n-3 LCPUFAs in Patients With Colorectal Cancer

University of Copenhagen50 enrolled

Overview

The aim of this study is to determine the effects of n-3 PUFAs on weight, physical funktion and quality of life in patients with colorectal cancer.

Primary outcomes: * Weight * Physical function * Hand-grip strength Secondary outcomes: * Quality of life * Mid-upperarm circumference * Incorporation of n-3 PUFAs into cell membranes

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Cancer Cachexia Side Effects Quality of Life

Interventions

Fish OilDIETARY_SUPPLEMENT

8 weeks, 2.2 G EPA/day

PlaceboDIETARY_SUPPLEMENT

Placebo

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ≥18 years * Patients with diagnosed colorectal cancer with metastases treated with chemotherapy on Rigshospitalet, Copenhagen Exclusion Criteria: * \< 18 years * Patients in palliative care * patients with haemophilia * Patiens in treatment of anti-coagulation * Patients with genetic hyperkolesterolemia * Pre-dialytic patients (GFR\<15ml/min/1,73m2 eller kreatinin ≥500 mmol/L)

Locations (1)

Departmen of Oncology, Rigshospital

Copenhagen, Denmark

Outcomes

Primary Outcomes

Weight loss

Difference in weight (kg) from inclusion to 8 week status

Time frame: 8 weeks

Secondary Outcomes

quality of Life score

score - difference from inclusion to 8 week status (EORTC QLQ-C30 questionnaire)

Time frame: 8 weeks

Performance status - common daily abilities

combined scale - score - ADL

Time frame: 8 weeks

Data from ClinicalTrials.gov

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