Magnetic Resonance Imaging (MRI) to Predict Outcomes of Pancreatic Ductal Adenocarcinoma (PDAC)

Cedars-Sinai Medical Center36 enrolled

Overview

The purpose of this study is to assess if Six-Dimensional Magnetic Resonance Imaging (6D-MRI) is effective in predicting outcomes in patients with pancreatic ductal adenocarcinoma (PDAC).

The overarching goal of this pilot study is to evaluate the usefulness of a novel Magnetic Resonance Imaging (MRI) approach, which measure properties of tumor microenvironment (i.e. vascularity, fibrosis), to predict PDAC response to neoadjuvant therapy (NAT).

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

PDAC - Pancreatic Ductal Adenocarcinoma

Interventions

6D-MRIDIAGNOSTIC_TEST

Six-Dimensional Quantitative Dynamic Contrast Enhanced MRI

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pancreatic cancer patients (with resectable or borderline resectable or locally advanced tumors) who will undergo neoadjuvant chemotherapy * Patients able to undergo at least two sets of MRI sessions Exclusion Criteria: * Patients who have previously been treated for PDAC * Patients unable to undergo MRI exam w/contrast * Patients with metastatic pancreatic cancer visualized on index diagnostic imaging * Patients with certain metallic implants * Patients experiencing claustrophobia * Persons with allergy to animal dander or animal-instigated asthma

Locations (1)

Cedars-Sinai Medical Center

Los Angeles, California, United States

Outcomes

Primary Outcomes

Rate of progression-free survival from baseline

Progression-free survival will be determined by tumor activity assessed from radiomic features on imaging.

Time frame: 2 years

Number of participants with R0 resection

The rate of negative tumor resection margins for patient's with resectable cancer that undergo surgery.

Time frame: 2 years

Data from ClinicalTrials.gov

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