Opioid-free Anesthesia in Gynecologic Surgery

Seoul National University Bundang Hospital164 enrolled

Overview

Post-operative nausea and vomiting (PONV) is common for the patients undergoing laparoscopic gynecologic surgery. PONV is a major factor for patient dissatisfaction, delayed patient recovery and increased medical expenses. Opioid-reducing anesthetic regimen is known to decrease PONV and facilitate early recovery after surgery (ERAS) and has been widely accepted recently. In this study, the researchers intend to investigate whether opioid-free anesthesia effectively reduces PONV, and whether it is clinically safe and feasible.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

164

Conditions

Gynecologic Disease

Interventions

Opioid-free anesthesiaPROCEDURE

Anesthesia induction: thiopental, rocuronium, desflurane + single dose of alfentanil for endotracheal intubation Anesthesia maintenance: desflurane (without any opioid) Rescue for hypertension, tachycardia: desflurane and beta blocker/calcium channel blocker

Opioid-using anesthesiaPROCEDURE

Anesthesia induction: thiopental, rocuronium, desflurane + continuous infusion of remifentanil (TCI, Minto model) Anesthesia maintenance: desflurane, remifentanil Rescue for hypertension, tachycardia: desflurane, remifantanil and beta blocker/calcium channel blocker

Eligibility

Sex: FEMALEMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for laparoscopic gynecologic surgery (≥90 min) for benign or malignant uterine/ovarian disease * Age ≥ 19 * ASA (American Society of Anesthesiologists) class I-II Exclusion Criteria: * Uncontrolled hypertension * Untreated intracranial aneurysm * Severely impaired renal or hepatic function * Pregnancy * History of hypersensitivity for drugs used in the study * Patients not using NSAID-containing IV PCA (patient controlled analgesia) device post-operatively

Locations (1)

Seoul National Univ. Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

RECRUITING

Outcomes

Primary Outcomes

Total incidence of post-operative nausea

Y/N

Time frame: up to post-operative day 2