Efficacy of Ketamine in Post Anesthesia Recovery Room

University of Alberta143 enrolled

Overview

Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.

In this observational study, the investigators will monitor all patients with significant pain after any non-cardiac surgical intervention at the University of Alberta Hospital. After receiving an adequate dose of potent opioids (hydromorphone, morphine), the participants will receive up to 0,2-0,25 mg/kg IV ketamine bolus. In our center these boluses are given with 10-20mg increments. The adequate dose of opioids will be determined by the attending anesthesiologist, depending on what patients received intraoperatively and on their comorbidities. Pain scores will be assessed before and after administration of this drug. The incidence of any side effect after ketamine administration will be documented.

Study Type

OBSERVATIONAL

Enrollment

143

Conditions

Pain, Postoperative Ketamine Adverse Reaction Pain, Refractory Pain, Intractable Pain, Acute

Interventions

KetamineDRUG

IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria: * age ≥ 18 * significant pain despite narcotics used in post-anesthesia care unit * ketamine ordered by attending anesthesiologist Exclusion Criteria: * Patient refusal to receive ketamine * Patients undergoing cardiac surgery * Patients who received no narcotics * Contra-indication to receiving ketamine (determined by attending anesthesiologist)

Locations (1)

University of Alberta Hospital

Edmonton, Alberta, Canada

Outcomes

Primary Outcomes

Reduction in pain score after ketamine use in PACU

The Numeric Rating Scale (NRS-11) is an 11-point scale for patient self-reporting of pain. It is what is used most often in our recovery room for pain assessment. A score of 0/10 means no pain, and 10/10 means worst pain.

Time frame: in the immediate post-operative period in recovery room

Secondary Outcomes

Incidence of side effects after ketamine use

Time frame: in the immediate post-operative period in recovery room

Data from ClinicalTrials.gov

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