Extracorporeal membrane oxygenation (ECMO) has been used primarily in newborns since it was first successfully implemented in the 1970s, and has recently increased use in infants and young children. Venoarterial ECMO (VA-ECMO) is a temporary mechanical circulatory support for patients with cardiac failure. Because ECMO is invasive, appropriate use of antimicrobial agent, analgesic and sedatives is important to promote recovery. However, a large variability in drugs pharmacokinetics is expected in pediatric ECMO patients due to the combination of ECMO, drug characteristics and disease factor. This study aimed to evaluate whether the PK of drugs is influenced by VA-ECMO and to recommend the optimal dosing strategies for proposed drugs in pediatric patients receiving VA-ECMO.
Study Type
OBSERVATIONAL
Enrollment
50
Department of Thoracic and Cardiovascular Surgery, Yonsei University Health System
Seoul, South Korea
RECRUITINGSerum or plasma concentration
Serum or plasma concentration of vancomycin or meropenem or milrinone or dexmedetomidine or fentanyl
Time frame: Between day0 to day3 during ECMO
Serum or plasma concentration
Serum or plasma concentration of vancomycin or meropenem or milrinone or dexmedetomidine or fentanyl
Time frame: Between day0 to day3 after weaning off ECMO
Pharmacokinetic parameter: Volume of distribution
Volume of distribution of vancomycin or meropenem or milrinone or dexmedetomidine or fentanyl
Time frame: Between day0 to day3 during ECMO
Pharmacokinetic parameter: Volume of distribution
Volume of distribution of vancomycin or meropenem or milrinone or dexmedetomidine or fentanyl
Time frame: Between day0 to day3 after weaning off ECMO
Pharmacokinetic parameter: Clearance
Clearance of vancomycin or meropenem or milrinone or dexmedetomidine or fentanyl
Time frame: Between day0 to day3 during ECMO
Pharmacokinetic parameter: Clearance
Clearance of vancomycin or meropenem or milrinone or dexmedetomidine or fentanyl
Time frame: Between day0 to day3 after weaning off ECMO
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