Sulfur Amino Acids, Energy Metabolism and Obesity

University of Oslo61 enrolled

Overview

The primary objective of the trial is to establish the effects of dietary sulfur amino acid (SAA) restriction on body weight, body composition and energy expenditure in humans.

Dietary SAA restriction is an established model for increasing lifespan and improving metabolic health in animal studies. Data from human studies are limited. In this study the investigators will perform an 8-week dietary intervention with SAA restriction to characterise the effects on several parameters related to metabolic health including body weight, body composition, energy expenditure, lipid profile and gene expression profiles in adipose tissue. The aim is to translate findings from previous animal experiments to humans

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Overweight and Obesity

Interventions

Low SAA dietOTHER

Diet with low content of methionine and cysteine

High SAA dietOTHER

Diet with high content of methionine and cysteine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy participants with overweight and obesity (BMI 27-35 kg/m2) * Waist circumference \> 80 cm for women and \> 94 cm for men Exclusion Criteria: * Smoking * Presence of chronic disease * Established co-morbidities * Already on a vegan diet or have been the last month * Pregnancy * Breastfeeding the last 3 months * Unstable body weight the last 3 months * High intensity training \> 3 times weekly

Locations (1)

Centre for Clinical Nutrition, University of Oslo/Oslo University Hospital

Oslo, Norway