Eye Movements Recording Using a Smartphone: Comparison to Standard Video-oculography in Patients With Multiple Sclerosis

Association de Recherche Bibliographique pour les Neurosciences30 enrolled

Overview

This study aims to compare measurements obtained through the e-VOG application (mobile application, usable on mobile phones or tablets, to measure eye movements) with measurements from the standard video-oculography device (Eye-Tracker®T2), in patient with Multiple Sclerosis.

Based on literature, investigators hypothesize that it would be relevant to focus more broadly on subclinical abnormalities of oculomotricity in multiple sclerosis (MS). However, the difficulty of accessing video-oculography platforms (or eye-tracking devices) is probably one of the main limitations to performing this type of assessment. To respond this problem, the "Resources and Skills Center-Multiple Sclerosis" (CRC SEP) team at the Nice University Hospital Center (France) has developed a mobile application (named e-VOG), usable on mobile phones or tablets, to measure eye movements. e-VOG reproduces the classic paradigms of video-oculography to collect data similar to standard video-oculography recording (saccade latency and speed, anti-saccade error rate, presence of fixation abnormalities). e-VOG will not replace standard video-oculography platforms, because its technical characteristics are not as high. But investigators hypothesize that this application could constitute a screening tool for subclinical oculomotor abnormalities, usable by neurologists in consultation, directly on their mobile, which would make it possible to select a smaller population of patients in whom a further exploration by standard video-oculography would be indicated. Memory Center of the Rainier III Gerontologic Center (Princess Grace Hospital - Monaco) is equipped with a standard video-oculography device, also named eye-tracking device (Eye-Tracker®T2), which records eye movements at a high frequency and measures saccades parameters (latency, speed, amplitudes etc...). This study is a collaborative study between the Center Rainier III team and the CRC SEP team in Nice. Its objective will be to compare measurements obtained through the e-VOG application with measurements from the standard video-oculography device.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Multiple Sclerosis

Interventions

Eye-Tracker®T2 + e-VOGOTHER

* 1st step: eyes movements assessed with standard video-oculography device * 2° step: eyes movements assessed with e-VOG digital application * Patient study duration is about 30 minutes, the day the patient performs their standard video-oculography examination in routine care

e-VOG + Eye-Tracker®T2OTHER

* 1st step: eyes movements assessed with e-VOG digital application * 2° step: eyes movements assessed with standard video-oculography device * Patient study duration is about 30 minutes, the day the patient performs their standard video-oculography examination in routine care

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or Female. * 18 years old and above. * referred by a neurologist to perform a video-oculography (Eye-Tracking) examination as part of routine care. * with Multiple Sclerosis (defined according to McDonald's 2017 criteria). * covered by a health insurance system * volunteer, able to give free, informed and written consent. Exclusion Criteria: * General anaesthesia within 3 months. * Neurological, ophthalmological or general pathology preventing the realization of a video-oculography examination. * Oculomotor abnormality detectable on clinical examination by the neurologist prescribing the standard video-oculography examination.

Locations (1)

Centre Mémoire / Centre de Gérontologie Clinique Rainier III / Princess Grace Hospital

Monaco, Monaco

Outcomes

Primary Outcomes

Oculomotor profiles concordance

Analyze of the concordance of the profiles obtained between the e-VOG digital assessment and the standard video-oculography assessment. Evaluation criteria: For each assessment, patients will be classified into 3 profiles (Profile 1 = profile without oculomotor abnormality; Profile 2 = intermediate profile with 1 to 2 oculomotor abnormalities; Profile 3: profile with 3 to 4 oculomotor anomalies), based on the observation of 4 parameters (latency / speed / fixation disorders / presence of internuclear ophthalmoplegia), in accordance with the literature standards.

Time frame: Day 0

Secondary Outcomes

Latency during horizontal reflex saccades

Measure of Latency during an horizontal reflex saccades paradigm with e-VOG Compared to the one performed with standard video-oculography device. Evaluation criteria: latency (reaction time in ms).

Time frame: Day 0

Latency during vertical reflex saccades

Measure of Latency during a vertical reflex saccades paradigm with e-VOG Compared to the one performed with standard video-oculography device. Evaluation criteria: latency (reaction time in ms).

Time frame: Day 0

Velocity during horizontal reflex saccades

Measure of Velocity during an horizontal reflex saccades paradigm with e-VOG Compared to the one performed with standard video-oculography device. Evaluation criteria: velocity (mean and peak velocity) in °/s.

Time frame: Day 0

Velocity during vertical reflex saccades

Measure of Velocity during a vertical reflex saccades paradigm with e-VOG Compared to the one performed with standard video-oculography device. Evaluation criteria: velocity (mean and peak velocity) in °/s.

Time frame: Day 0

Data from ClinicalTrials.gov

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