The NEOPRENE project proposes to examine processes that are among the earliest precursors of cognitive functions and assess 1) the relationship between neonatal cognitive precursors and cortical structure, structural connectivity and functional connectivity at birth and 2) the relationship between neonatal cognitive precursors and neurodevelopment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
90
Brain activity will be measured using 128-channel EEG and 2 channel NIRS during tactile stimulation (15 minutes sequence of vibrations) while the newborn is asleep.
Structural (T1-T2), siffusion tensor imaging and blood-oxygen level dependant signal will be acquired in a subset of 40 subjects (20 minutes while asleep)
Cognitive evaluation at age 2 (Parental questionnaires on sensory profiles, executive functions and neurodevelopmental disorders screening, child tests : movement assessment battery, Laby, Head-toes-shoulders-knees)
Caen University Hospital
Caen, France
RECRUITINGElectroencephalography evoked response amplitude
Electrical field potential changes in the parietal and frontal cortices
Time frame: 35 weeks of gestational age
Near infrared spectroscopy evoked response amplitude
Oxygenated hemoglobin concentration changes in the somatosensory cortex
Time frame: 35 weeks of gestational age
Grey matter volume in the somatosensory cortex
Thickness measured on T2 images in magnetic resonance imaging
Time frame: 35 weeks GA
Frontal-parietal structural connectivity
Tractography using Diffusion tensor Imaging in magnetic resonance imaging
Time frame: 35 weeks GA
Frontal-parietal functional connectivity
Synchronization at rest using blood-oxygen level dependent signal in magnetic resonance imaging
Time frame: 35 weeks GA
Quality of cognitive development
Qualitative composite assessment using clinical interview, routine pediatric screening and questionnaires (full sensory profile, preschooler Behavior Rating Inventory of Executive Function)
Time frame: 2 years old
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