Identification of Pathophysiological Pathways and Therapeutic Targets in Primary Stomatodynia by Salivary Metabolomics

University Hospital, Tours53 enrolled

Overview

Burning mouth syndrome (BMS) is defined by a chronic oral pain affecting especially postmenopausal women. Its physiopathology is still unknown and several hypotheses have been put forward to explain this syndrome, such as neurological, hormonal or inflammatory process. The recent development of salivary metabolomic profiling in oral diseases has led to the identification of potential pathways in such disorders. The aim of this study is to analyze the salivary metabolomic in BMS patients compared to healthy controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Primary Burning Mouth Syndrome

Interventions

Salivic sample

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * For cases : primary Burning Mouth Syndrome, based on the IHS diagnosis criteria * For cases : being able to realise the salivary collection * For controls : no primary BMS * For controls : being able to realise the salivary collection Exclusion Criteria for both groups: * Treatment by antibiotics in the previous month * New treatment in the previous two weeks * Active smoking * Active infectious or inflammatory oral disease * Systemic disease that could have an impact on the salivary metabolome or on the neurological system * Being under legal guardianship * Opposition to the processing of personal data

Outcomes

Primary Outcomes

Comparative analysis of salivary metabolomic profiles between cases (primary BMS) and controls

metabolites will be measured in saliva by chromatography-mass spectrometry

Time frame: at inclusion

Secondary Outcomes

Comparative analysis of salivary neuropeptides between cases (primary BMS) and controls

quantitative assessment of levels of neuropeptides (NGF, histamine, tryptase, kallicrein) will be assessed in saliva in cases and controls

Time frame: at inclusion

Comparative analysis of salivary hormones between cases (primary BMS) and controls

quantitative assessment of levels of steroid hormones (cortisol, 11-desoxycortisol, DHEA, SDHEA, progesterone, 17-hydroxyprogesterone, testosterone, androstenedione) will be assessed in saliva in cases and controls

Time frame: at inclusion

Comparative analysis of salivary inflammatory cytokines between cases (primary BMS) and controls

quantitative assessment of levels of cytokines (IL-2, IL-6, IL-18, TNFα) will be assessed in saliva in cases and controls

Time frame: at inclusion

Correlation between salivary biomarkers and pain characteristics

metabolites profile, salivary neuropeptides, hormones and cytokines will be compared according to the category of pain (type I-II-III, neuropathic pain score DN4\>4)

Time frame: at inclusion

Identification of Pathophysiological Pathways and Therapeutic Targets in Primary Stomatodynia by Salivary Metabolomics

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes