To better understand the role of inflammation in COVID-19, we established the Michigan Medicine COVID-19 Cohort (M2C2). M2C2 is a funded and ongoing cohort which has currently enrolled over 1500 adult patients (≥18 years) with severe COVID-19 admitted at the University of Michigan. The purpose of M2C2 is to define the in-hospital course of these patients and understand the role of inflammation as a determinant of organ injury and outcomes in COVID-19.
The Michigan Medicine COVID-19 Cohort is a prospective observational cohort study of patients hospitalized specifically for COVID-19 at the University of Michigan Health System in Ann Arbor. Medical records of all consecutive patients with a positive SARS-CoV-2 are reviewed, and patients with confirmed SARS-CoV-2 infection but not primarily admitted for COVID-19 were excluded. Biologic samples of patients enrolled in M2C2 were collected, and clinical characteristics including in-hospital outcomes were characterized in detail. Biomarkers measured include, but not be limited to, soluble urokinase plasminogen activator receptor (suPAR), high sensitive C reactive protein (hs-CRP), brain natriuretic protein (BNP), high sensitive troponin T (hsTnT), interleukin 6 (IL-6), osteopontin, a2-antiplasmin.
Study Type
OBSERVATIONAL
Enrollment
3,402
Biomarkers were measured on blood samples collected within 48 hours of admission
University of Michigan
Ann Arbor, Michigan, United States
Death, need for mechanical ventilation or need for dialysis
The primary outcome is a composite endpoint, which is defined as the need for mechanical ventilation, the need for dialysis, or in-hospital death.
Time frame: Total duration of the Covid-19 hospitalization, up to 1 year
All-cause death
Time frame: Total duration of the Covid-19 hospitalization, up to 1 year
Need for mechanical ventilation
Time frame: Total duration of the Covid-19 hospitalization, up to 1 year
Need for dialysis
Time frame: Total duration of the Covid-19 hospitalization, up to 1 year
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