Immune Profile and Prognosis of Malignant Liver Tumors With Radiofrequency Ablation (RFA) Therapy

Inclusion Criteria: * Disease characteristics: Patients with primary or metastatic liver cancer judged by histology * Age: 20 years old or older * Life expectation: at least 3 months * Hematology: 1. Platelet count: at least 50,000/mm\^3 2. Prothrombin time (PT) or partial thromboplastin time (PTT): no more than 1.5 times the control group 3. Creatinine: no more than 2.5 mg/dl * No pregnancy, no rhythm adjuster or other implantable device * There are no uncontrollable responses to this study * Other malignant tumors, except for therapeutic non-melanoma skin cancer or cervical cancer 5 years before entering the study inside. * The number of liver tumors is less than three, the size is less than three centimeters, or the size of a single tumor is less than five centimeters, and those who want to undergo radiofrequency ablation are treated. * The clotting time is normal and the number of platelets needs to be greater than 50,000, total bilirubin is less than 3 mg/dl, controllable ascites, no extrahepatic metastasis and portal vein invasion, and those who want to undergo radiofrequency ablation. * The patient refuses or is unable to perform surgery (eg, If the age is too old, for those who want to undergo radiofrequency ablation). * Patients and their families must fully understand and agree to perform radiofrequency ablation procedures. Exclusion Criteria: * There are people with central nervous system metastases. * Measure lesions only by previous radiotherapy or topical treatment. * Biliary obstruction did not undergo adequate drainage procedures prior to enrollment. * White blood cells (WBC) are less than 3,500 / mm3 and absolute neutrophil count (ANC) is less than 1,500 / mm3, platelets less than 100,000 / mm3 * Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) is greater than 5.0 times the upper limit of the normal range (ULN). * Serum total bilirubin levels are equal to or greater than 2.0 mg / dl. * Serum creatinine greater than 1.5 mg / dl. * There are peripheral neuropathies greater than grade 1. * Concomitant diseases that may accumulate via chemotherapy. For example, active, noncontrolled infection or other activity, non-control Systemic diseases such as congestive heart failure, angina pectoris, respiratory insufficiency, arrhythmia. * Those who are treated concurrently with other research drugs or other anti-cancer therapies. * Pregnant or lactating women, or women with fertility potential, unless reliable and appropriate methods of contraception are used.