VDR SNPs & 25OHD Correlated With Dyslipidemia

Shenzhen Center for Chronic Disease Control1,987 enrolled

Overview

The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.

Study Type

OBSERVATIONAL

Enrollment

1,987

Conditions

Dyslipidemias Single Nucleotide Polymorphism

Interventions

No intervention.OTHER

No intervention.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 81 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 1\) ≥ 20 years old Han Chinese; * 2\) living in Shenzhen for \> 2 years; * 3\) free of liver diseases, renal diseases, and any cancers in the past 6 months; and * 4\) not in pregnancy for women. Exclusion Criteria: * 1\) had severe organic diseases, * 2\) had acute infection symptoms, allergic diseases, and malignant tumors, * 3\) had a family history of genetic diseases, * 4\) took VD supplements in the past 6 months, * 5\) took medicines to control lipid levels within 12 hours, or * 6\) took diuretics, did strenuous exercise, or overate within 24 hours before the test.

Locations (1)

Shenzhen Center for Chronic Disease Control

Shenzhen, Guangdong, China

Outcomes

Primary Outcomes

SNPs of VDR

Polymorphisms of vitamin D receptor gene: Cdx2, Fok1, Apa1, and Taq1

Time frame: 6 months

lipid profiles

Serum concentrations of TG, TC, LDLC, and HDLC

Time frame: 6 months

25OHD

Plasma 25-hydroxyvitamin D concentration

Time frame: 6 months

Data from ClinicalTrials.gov

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