Improving Neuroprotective Strategy for Ischemic Stroke After Thrombectomy Followed by DELP (INSIST-DELP)

Inclusion Criteria: * Age ≥18 years; * acute anterior circulatory cerebral infarction with large vessel occlusion; * NIHSS≥6 before endovascular treatment; * good recanalization (TICI 2b-3); * time from onset to groin puncture is less than 8 hours; * time from recanalization to DELP is less than 2 hours; * Premorbid mRS 0 or 1; * Signed informed consent. Exclusion Criteria: * poor recanalization (TICI 1-2a); * Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia （ \<100000/mm3; * Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis; * Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg); * Previous allergy to heparin or calcium; * hypoproteinemia; * Unsuitable for this clinical studies assessed by researcher.