A Clinical Pharmacology Study to Evaluate the Effect of GYM329 on Disuse Muscle Atrophy in Healthy Volunteer

Inclusion Criteria: * Able and willing to provide written informed consent and to comply with the study protocol * Healthy men aged from 18 to less than 40 years at the time of consent * Right leg dominant * Agreed to limit physical activity as directed by study site staff from the time of informed consent until the end of the muscle strength evaluation period (completion of Day 43) * BMI is between 18.5 and less than 25.0 at screening * Agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and agreement to refrain from donating sperm. Exclusion Criteria: * History of congenital myopathy * Congenital thrombophilia * Previous or current VTE * History of hip or limb surgery, spine or spinal cord surgery, or laparotomy (excluding laparotomy for appendicitis or inguinal hernia), or laparoscopic surgery (e.g. cholecystectomy) * History of fracture of the pelvis or open/compound fracture of lower limb, or history of fracture within 3 years prior to screening, excluding digit fracture * History of severe trauma, trauma requiring surgical intervention, or trauma with organ injury which deemed as clinically significant by the investigator * Previous or current medical condition that could lead to thrombosis as judged by the investigator * Angiography within 6 months before first study treatment administration * Current Grade ≥ 3 thermal burn or history of Grade ≥ 3 thermal burn within 3 months prior to study treatment administration * Unable to wear compression stockings * History of heparin-induced thrombocytopenia or hypersensitivity to the LMWH and to the heparin or any other clinically significant contra-indications for use of LMWH * Participation in bodybuilding or full time employment in a physically demanding occupation * Immobilization, surgery, or traumatic injury of the arm within 90 days before first study treatment administration * Traumatic injury of the leg within 6 months before first study treatment administration * Immobilization or surgery of the leg within 6 months before first study treatment administration * Immobilization of the leg for 2 or more weeks within 12 months before first study treatment administration * Contraindication for MRI * Habitual excessive over- or under-eating * Any condition that may interfere with assessment of local pain and pruritus at the injection site