This study is a multicenter non-interventional observational prospective registry. This non-interventional study (NIS) does not imply any intervention into a routine clinical practice, including choice of treatment modality or special methods of investigation. The study will include only those patients who sign the informed consent form (ICF) after explanation of the study objectives and methods by the study physician. Planned study population consists of 20 000 adult outpatients with HF. All patients with HF who signed an ICF will be included to this study. Planned number of study sites is 150 outpatient centers in about 50 regions (in order to describe characteristics of outpatients with HF in different regions in the most comprehensive way). Expected inclusion period duration - 24 months OR reaching 20 000 patients, if this takes less than 24 months. Planned follow-up period duration for 1 patient is about 52 weeks (12 months), which includes 3 visits (visit 1 - inclusion; visit 2 - approximately 6 months after inclusion; visit 3 - approximately 12 months after inclusion)
Study Type
OBSERVATIONAL
Enrollment
19,990
Research Site
Akhtubinsk, Astrakhan Oblast, Russia
Research Site
Stary Oskol, Belgorod Oblast, Russia
Research Site
Gurievsk, Kaliningrad Oblast, Russia
Research Site
Rodniki Settlement, Kaliningrad Oblast, Russia
Research Site
Korolyov, Moscow Oblast, Russia
Research Site
Mean age
At baseline of this study
Time frame: Baseline
Proportion of men and women
At baseline of this study
Time frame: Baseline
Proportion of patients with negative lifestyle factors
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with different etiology of CHF
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with a history of HF comorbidities and conditions of special interest
At baseline of this study
Time frame: Baseline
Mean duration of comorbidities listed in previous paragraph (p. 5) (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF)
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with different chronic comorbidities
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with history of COVID-19
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with vaccination
At baseline of this study
Time frame: Baseline
Proportion of patients with different types of HF based on LVEF
At baseline of this study
Time frame: Baseline
Proportion of patients with T2DM comorbid with different types of HF based on LVEF
At baseline of this study
Time frame: Baseline
Mean HbA1c (for patients with T2DM) (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF);
At baseline of this study
Time frame: Baseline
Proportions of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with different levels of HbA1c (for patients with T2DM)
At baseline of this study
Time frame: Baseline
Mean BMI (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF)
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with different BMI levels
The BMI will be calculated using a formula based on the patient's anthropometric data collected at visit q (height measured in meters and body weight measured in kilograms). BMI (kg / m2) is calculated using the formula: BMI = weight (kg) / (height2 (m2))
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with different functional classes of CHF according to NYHA classification based on patient symptoms of HF
At baseline of this study
Time frame: Baseline
Mean NT-proBNP level (or BNP)
NT-proBNP is measured in pg / mL. At baseline of this study
Time frame: Baseline
Mean heart rate (HR) (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF);
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with different functional classes of HF according to SHOKS level
1. Functional Class I - ≤3 points; 2. Functional Class II - from 4 to 6 points; 3. Functional Class III - from 7 to 9 points; 4. Functional Class IV - more than 9 points; At baseline of this study.
Time frame: Baseline
Mean SBP (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF)
SBP - Systolic blood pressure. At baseline of this study.
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with SBP
1. \<90 mm Hg; 2. 90-99 mm Hg; 3. 100-109 mm Hg; 4. 110-119 mm Hg; 5. 120-139 mm Hg; 6. 140-159 mm Hg; 7. ≥160 mm Hg; At baseline of this study
Time frame: Baseline
Mean Diastolic blood pressure (DBP) (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF)
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with DBP
1. \<90 mm Hg; 2. ≥90 mm Hg; At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with concomitant CKD of different stages
eGFR = 141 x min(SCr/κ, 1)\^α x max(SCr/κ, 1)\^-1.209 x 0.993\^Age x 1.018 \[if female\] x 1.159 \[if Black\], where eGFR (estimated glomerular filtration rate) = mL/min/1.73 m\^2, SCr (standardized serum creatinine) = mg/dL, κ = 0.7 (females) or 0.9 (males), α = -0.329 (females) or -0.411 (males), min = indicates the minimum of SCr/κ or 1, max = indicates the maximum of SCr/κ or 1, age = years. At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with CKD and different levels of albumin-to-creatinine ratio in a spot urine sample
1. \<30 mg/g; 2. 30-300 mg/g; 3. \>300 mg/g; At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample, in subgroups of patients with HFrEF, HFmEF and HFpEF, in sub-subgroups of patients with CKD and without CKD) with concomitant hyperkalemia (K+ level >5,5 mmol/L)
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample, in subgroups of patients with HFrEF, HFmEF and HFpEF, in sub-subgroups of patients with CKD and without CKD) with concomitant hypokalemia (K+ level <3,5 mmol/L)
At baseline of this study
Time frame: Baseline
Mean LVEF (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF)
At baseline of this study
Time frame: Baseline
Mean K+ level (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF)
At baseline of this study
Time frame: Baseline
Mean Na+ level (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF)
At baseline of this study
Time frame: Baseline
Mean hemoglobin level (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF)
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with different rhythm
1. Sinus rhythm; 2. AF / AFl; 3. Pacemaker rhythm; At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with different QRS duration
1. \<130 ms; 2. 130-150 ms; 3. \>150 ms; At baseline of this study
Time frame: Baseline
Proportion of patients receiving different classes of drugs for treatment of HF
* ACE inhibitors (duration, dosage, proportion of patients receiving: \<50% of target dose, 50-100% of target dose, ≥100% of target dose); * B-blockers (duration, dosage, proportion of patients receiving: \<50% of target dose, 50-100% of target dose, ≥100% of target dose); * ARBs (duration, dosage, proportion of patients receiving: \<50% of target dose, 50 100% of target dose, ≥100% of target dose); * MRAs (duration, dosage, proportion of patients receiving: \<50% of target dose, 50 100% of target dose, ≥100% of target dose); * ARNI (duration, dosage, proportion of patients receiving: \<50% of target dose, 50 100% of target dose, ≥100% of target dose); At baseline of this study
Time frame: Baseline
Proportion of patients with HFrEF with implantable devices
* Implantable cardioverter-defibrillator (ICD) (recommended; implanted); * Cardiac resynchronisation therapy (CRT) (recommended; implanted); * CRT with defibrillation (CRT-D) (recommended; implanted); * Left ventricular assist device (LVAD); At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with cardiac surgery and endovascular procedures
* Revascularisation with PCI; * Revascularisation with CABG; * Valvular surgery; * Heart transplantation; At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) receiving dual disease-modifying therapy
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) receiving triple disease-modifying therapy
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) receiving quadruple disease-modifying therapy
At baseline of this study
Time frame: Baseline
Proportion of patients (in total sample and subgroups of patients with HFrEF, HFmEF and HFpEF) with CHF receiving different classes of glucose lowering drugs and their combinations for T2DM treatment
* Modification of diet and lifestyle only; * Metformin; * Sulfonylureas; * Inhibitors of dipeptidyl peptidase-4 (iDPP4); * iSGLT2; * Glucagon-like peptide-1 receptor agonists (GLP1 RA); * Acarbose; * Insulins. At baseline of this study
Time frame: Baseline
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