Efficacy of SJ733 in Adults With Uncomplicated Plasmodium Falciparum or Vivax Malaria

Inclusion Criteria: 1. Male or female, aged 18 to 70 years of age (inclusive) at screening. 2. Body weight between 45 kg and 90 kg inclusive 3. Presence of mono-infection of P. falciparum or P. vivax confirmed by: 1. Fever, as defined by axillary temperature ≥ 37.5°C or oral/rectal/tympanic temperature ≥ 38°C, or history of fever in the previous 24 hours (history of fever must be documented) and, 2. Microscopically confirmed parasite infection: 1,000 to 40,000 asexual parasite count/µL blood 4. Written informed consent provided by participant, in accordance with local practice. If the participant is unable to write, witnessed consent is permitted according to local ethical considerations. 5. Ability to swallow oral medication. 6. Ability and willingness to participate and to comply with the study requirements 7. Agreement to hospitalization for at least 102 hours and/or until malarial parasites are not detected by microscopy on 2 consecutive occasions. 8. Agreement to come back to the hospital on Days 7, 10 or 11, 14, 17 or 18, 21, 24 or 25, 28, 35, and 42. 9. Women of child-bearing potential, has a negative pregnancy test at screening, and agrees to comply with one of the following during the treatment stage of the study and for a period of 90 days after stopping study drug: 1. Use of oral, implantable, or injectable hormonal contraceptive, either combined or progestogen alone used in conjunction with barrier method as defined below. 2. Use of an intrauterine device with a documented failure rate of \<1% per year. 3. Barrier method consisting of either condom or diaphragm. 4. Male partner who is sterile prior to the female subject's entry into the study and is the sole sexual partner for that female. 5. Complete abstinence from intercourse for 2 weeks prior to administration of study drug, throughout the study and for a period of 90 days after stopping study drug. Exclusion Criteria: 1. Signs and symptoms of severe/complicated malaria according to the World Health Organization Criteria 2010 (Attachment 1: Definition of Severe Malaria) 2. Mixed Plasmodium infection. 3. Severe vomiting, defined as more than three times in the 24 hours prior to inclusion in the study, or severe diarrhea defined as 3 or more watery stools per day. 4. Severe malnutrition (defined as the weight-for-height being below -3 standard deviation or less than 70% of median of the NCHS/WHO normalized reference values) 5. Presence of a significant medical or psychiatric condition, or any other serious or chronic clinical condition requiring hospitalization, or any other condition that in the opinion of the investigator precludes participation in the study. 6. Female patients must not be either lactating or pregnant as demonstrated by a negative serum point-of-care pregnancy test pre-dose (the result of the pre-dose assessment must be confirmed negative prior to dosing). 7. Employment under the direct supervision of the investigators or study staff. 8. Clinically significant alterations to hematologic or clinical chemistry parameters that in the opinion of the investigator precludes participation in the study, including: 1. AST/ALT \> 3 x upper limit of normal range (ULN) and total bilirubin is normal 2. AST/ALT \> 2 x ULN and total bilirubin is \>1 and \<1.5 x ULN and conjugated bilirubin is \> 35% of the total bilirubin 3. Total bilirubin \> 1.5 x ULN 4. Serum creatinine levels \> 2 x ULN 5. Hb level \< 8 g/dL 6. Platelet level \< 50,000/mm3 9. Participation in a clinical study of another investigational small molecule within 30 days or investigational biologic within 90 days prior to study enrollment or planning to begin such participation during the study. 10. Have received any antimalarial treatment (alone or in combination) in the past containing: 1. Piperaquine, mefloquine, naphthoquine or sulphadoxine / pyrimethamine within the previous 6 weeks 2. Amodiaquine or chloroquine within the previous 4 weeks 3. Any artemisinin (artesunate, artemether, arteether or dihydroartemisinin) quinine, halofantrine, lumefantrine and any other anti-malarial treatment or antibiotics with antimalarial activity (including cotrimoxazole, tetracyclines, quinolones and fluoroquinolones, and azithromycin) within the past 14 days 11. Any medication from the list of prohibited medications.