Multicenter Study on Laparoscopic Total Gastrectomy for Advanced Gastric Cancer

Shanghai Zhongshan Hospital1,018 enrolled

Overview

CLASS-07 trial is a prospective, multicenter, randomized controlled trial for comparison of long-term outcomes between laparoscopic total gastrectomy (LTG) and open total gastrectomy (OTG) in patients with locally advanced gastric cancer (clinical stage T2-4aN0-3M0). The primary purpose of this study is to evaluate the overall survival and determine the efficacy of LTG compared with OTG for locally advanced gastric cancer. The second purpose is to evaluate the 3-year overall survival rate, 3-year disease free survival rate, morbidity and mortality rates, 3-year recurrence pattern and postoperative recovery course of the patients enrolled in this study.

Gastric cancer is a significant global health problem, especially in East Asia. With an increase in the incidences of proximal gastric cancer over the last decades, the value of total gastrectomy is more emphasized. Laparoscopic total gastrectomy (LTG) has become an attracting option for surgeons due to its well-known advantages. However, more evidence is needed to support the safety and efficacy of LTG in locally advanced gastric cancer. Recently，a multicenter, open-label, noninferiority, randomized clinical trial (CLASS-02) launched by Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group compared the safety of LTG for clinical stage I gastric cancer with open total gastrectomy (OTG). The overall morbidity and mortality rates were 19.1% in the LTG group and 20.2% in the OTG group, which was not significantly different (rate difference, -1.1%). This study demonstrated that LTG can be safely performed by experienced surgeons for clinical stage I gastric cancer. However, there hasn't been any prospective randomized clinical trial study evaluating the safety and efficacy of LTG in advanced gastric cancer. This CLASS-07 trial is a prospective, multicenter, randomized controlled trial for comparison of long-term outcomes between LTG and OTG in patients with locally advanced gastric cancer (clinical stage T2-4aN0-3M0). The primary purpose of this study is to evaluate the overall survival and determine the efficacy of LTG compared with OTG for locally advanced gastric cancer. The second purpose is to evaluate the 3-year overall survival rate, 3-year disease free survival rate, morbidity and mortality rates, 3-year recurrence pattern and postoperative recovery course of the patients enrolled in this study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Aged 18-75 years 2. Tumor located in the middle or upper third of the stomach, and curative resection is expected to be achievable by total gastrectomy with D2 lymphadenectomy (also apply to multiple primary cancers); 3. Primary lesion is pathologically diagnosed as gastric adenocarcinoma, such as papillary adenocarcinoma, tubular adenocarcinoma, mucinous adenocarcinoma, poorly cohesive carcinoma (including signet ring cell carcinoma and other variants), and mixed adenocarcinoma; 4. Clinical stage T2-4aN0-3M0 (According to AJCC-8th TNM staging system); 5. Expected survival \> 6 months 6. No invasion to Z-line; 7. BMI (Body Mass Index) \< 30 kg/m2 8. No history of upper abdominal surgery (except for laparoscopic cholecystectomy); 9. No prior treatment of chemotherapy, radiotherapy, targeted therapy, immunotherapy, etc 10. Preoperative performance status (ECOG，Eastern Cooperative Oncology Group) of 0 or 1 11. Preoperative ASA (American Society of Anesthesiologists) scoring: I-III 12. Sufficient organ functions 13. Written informed consent Exclusion Criteria: 1. Preoperative examinations indicate regional fusion of enlarged lymph nodes (max diameter ≥ 3.0cm) or enlargment of spleen hilus lymph nodes 2. Women during pregnancy or breast-feeding 3. Synchronous or metachronous (within 5 years) malignancies 4. Body temperature ≥ 38℃ before surgery or infectious disease with a systemic therapy indicated 5. Severe mental disease 6. Severe respiratory disease, FEV1 \< 50% of predicted 7. Severe hepatic and renal dysfunction 8. Unstable angina pectoris or history of myocardial infarction within 6 months 9. History of cerebral infarction or cerebral hemorrhage within 6 months 10. Continuous systemic steroid therapy within 1 month (except for topical use) 11. Gastric cancer complications (bleeding, perforation, obstruction) that requiring emergency surgery 12. Patients are participating or have participated in another clinical trial (within 6 months)

Outcomes

Primary Outcomes

Overall survival

Overall survival (OS) was defined as the time from randomization to death from any cause

Time frame: 3 years

Secondary Outcomes

3-year overall survival rate

\# of patients who are still alive at 3 years out of all study patients

Time frame: 3 years

3-year disease free survival rate

\# of patients who are free of gastric cancer at 3 years out of all study patients

Time frame: 3 years

Early morbidity rate

The early morbidity are defined as the event observed within 30 days following surgery, including intraoperative and postoperative complications

Time frame: 30 days

Early mortality rate

The early mortality are defined as the event observed within 30 days following surgery, including intraoperative and postoperative death

Time frame: 30 days

3-year recurrence pattern

Recurrence patterns are classified into five categories at the time of first diagnosis: locoregional, hematogenous, peritoneal, distant lymph node, and mixed type

Time frame: 3 years

Postoperative recovery course

Time to first ambulation, flatus, liquid diet, and soft diet are used to assess the postoperative recovery course, which is a composite outcome measure.

Time frame: 30 days

Multicenter Study on Laparoscopic Total Gastrectomy for Advanced Gastric Cancer

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts