Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients. Weaning parameters and spontaneous breathing trial are used to investigate the indication and predict the successful extubation. Hemodynamic stability and physical reserve are important indicators as well. Microcirculation parameters are known to be more sensitive to the change of hemodynamic status than macrocirculation parameters. We hypothesize that the change of sublingual microcirculation before and after spontaneous breathing trial is different between the the patients with successful extubation and the patients with failed extubation. Thus, this study measures sublingual microcirculation in patients receiving spontaneous breathing trial and record the extubation status (successful or failed). The microcirculation parameters before and after spontaneous breathing trial are compared between the the patients with successful extubation and the patients with failed extubation.
Study Type
OBSERVATIONAL
Enrollment
59
Sublingual microcirculation images were recorded using an incident dark-field video microscope
National Taiwan University Hospital
Taipei, Taiwan
Initial total vessel density
Total vessel density measured by Cytocam before and after spontaneous breathing trial
Time frame: 0 hour
Change of total vessel density
The difference between the total vessel density measure by Cytocam before and after spontaneous breathing trial
Time frame: baseline and 1 hour
Initial perfused vessel density
Perfused vessel density measured by Cytocam before spontaneous breathing trial
Time frame: 0 hour
Change of perfused vessel density
The difference between the perfused vessel density measure by Cytocam before and after spontaneous breathing trial
Time frame: baseline and 1 hour
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