Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?

Centre Hospitalier Universitaire, Amiens544 enrolled

Overview

The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

544

Conditions

Pulmonary Embolism Hematopoiesis

Interventions

blood sampleBIOLOGICAL

Blood sample withdrawal in order to perform DNA sequencing

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening. * For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening. Exclusion Criteria: * Age superior to 65 years old, * Active cancer

Locations (1)

CHU Amiens

Amiens, France

RECRUITING

Outcomes

Primary Outcomes

Variation of CHIP markers between patients groups

Variation of CHIP markers (clonal hematopoiesis of indetermined prognosis ) between patients groups. CHIP concept have been defined as a mutation of preleukemic genes at an allelic variation inferior to 2% associated with normal complete blood count.

Time frame: up to 2 years

Central Contacts

Simon SOUDET, MD

CONTACT

03 22 88 72 89 soudet.simon@chu-amiens.fr

Data from ClinicalTrials.gov

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