Overlap FGIDs and Genetic Polymorphism

Seoul National University Bundang Hospital800 enrolled

Overview

1. To analyze the prevalence of overlap syndromes among NERD or RH, FD, and IBS patients, and to identify and to compare the differences in their characteristics and symptoms, and to determine their risk factors. 2. To identify the differences in clinical features according to sex and gender. 3. To analyze the effect of genetic polymorphisms on overlap FGIDs over long-term follow-up period.

Study Type

OBSERVATIONAL

Enrollment

800

Conditions

Functional Gastrointestinal Disorders Overlap Syndromes

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: FGID group * No organic diseases in routine laboratory tests, abdominal imaging, esophagogastroscopy, and colonoscopy * NERD or reflux hypersensitivity (RH): typical heartburn occurring at least once a week without visible esophageal mucosal break detected by endoscopy * FD or IBS: based on the Rome III criteria Control group \- Subjects who underwent GI evaluations as part of health check-up or for other problems, such as mild abdominal discomfort or pain for a relatively short period of time, but had no organic problems during GI endoscopy Exclusion Criteria: * history of GI surgery except appendectomy * inflammatory bowel disease * any malignancy, or systemic diseases requiring chronic medication except for hypertension and diabetes mellitus * pregnant or lactating women * hepatic, biliary, or psychiatric disorders requiring medication.

Outcomes

Primary Outcomes

Symptom severity score (5 Likert scale, from 0 to 4)

FGID symptom severity score score by K-BDQ

Time frame: per 16 years

Hospital anxiety and depression scale (HADS)

by HADS questionnaire

Time frame: per 16 years

Genetic polymorphisms of SLC6A4 5-HTTLPR, GNB3, ADRA2, TNFA, IL10 gene

Time frame: per 16 years

Secondary Outcomes

Prevalence of overlap syndromes among FGIDs(NERD or RH, FD, and IBS) patients

Time frame: per 16 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.