This study will evaluate the associations between vascular parameters and clinical outcomes in patients hospitalized with COVID-19. The vascular function and structure of individuals with COVID-19 admitted to the General Hospital of the University of Sao Paulo will be assessed in the first 72 hours of hospitalization. Then, participants will be followed up until hospital discharge/death. Logistical regressions will be run to evaluate if vascular function/structure can predict ICU admissions, intubation, thrombosis or death.
This is a prospective cohort study conducted at the General Hospital of the University of São Paulo Medical School (HCFMUSP). Male and female participants with SARS-CoV-2 and recently admitted to the hospital (≤ 72 hours) will be recruited at the emergency department and outpatient clinics at the HCFMUSP. Immediately upon recruitment, participants will perform the assessment of flow mediated dilation of the brachial artery and the assessment of carotid intima-media thickness. Subsequently, they will be followed during the entire period of hospitalization. The present study will employ as primary endpoint a composite of ICU admission, intubation or mortality during the period of hospitalization. Cardiovascular complications, such as arterial (AE), deep venous (DVP) or pulmonary embolism (PE) , acute myocardial infarction (AMI), stroke, cardiac arrest, atrial fibrillation and acute kidney injury will be considered secondary endpoints. The association between the vascular parameters and clinical outcomes will be examined by a multivariate logistic regression.
Study Type
OBSERVATIONAL
Enrollment
250
Hospital das Clínicas da Faculdade de Medicina da USP - HCFMUSP
São Paulo, Brazil
RECRUITINGComposite outcome
A composite outcome including ICU admission, intubation and all-cause mortality
Time frame: Up to hospital discharge, an average of 4 weeks
All-cause mortality
All-cause mortality rate along the study
Time frame: Up to hospital discharge, an average of 4 weeks
ICU admission
Admission to the ICU along the study
Time frame: Up to hospital discharge, an average of 4 weeks
Intubation
Necessity of intubation along the study
Time frame: Up to hospital discharge, an average of 4 weeks
Cardiovascular complications
Cardiovascular complications, such as arterial, deep venous or pulmonary embolism, acute myocardial infarction, stroke, cardiac arrest, atrial fibrillation and acute kidney injury
Time frame: Up to hospital discharge, an average of 4 weeks
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