OCTA and Polypoidal Choroidal Vasculopathy

Federico II University60 enrolled

Overview

To investigate the structural and vascular features of choroid in patients affected by PCV after Ranibizumab intravitreal injection.

Polypoidal choroidal vasculopathy represents a distinct form of choroidal neovascularization. The study investigated the changes in choroidal vascular network after anti-VEGF therapy using optical coherence tomography angiography, a novel and non invasive diagnostic technique that allows to better understand the pathophysiologic mechanism of this neovascularization.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Polypoidal Choroidal Vasculopathy

Interventions

Ranibizumab InjectionDRUG

Three monthly intravitreal injections of Ranibizumab

Eligibility

Sex: ALLMin age: 60 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age older than 60 years * diagnosis of polypoidal choroidal vasculopathy * absence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * absence of significant lens opacities, low-quality OCT-A images. Exclusion Criteria: * age older than 80 years * absence of diagnosis of polypoidal choroidal vasculopathy * presence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * presence of significant lens opacities, low-quality OCT-A images.

Locations (1)

University of Naples "Federico II"

Naples, Italy

Outcomes

Primary Outcomes

Study of vascular features of choroid in polypoidal choroidal vasculopathy after intravitreal injections of Ranibizumab

The effectiveness of Ranibizumab injections for treating PCV using optical optical coherence tomography angiography. The parameters analyzed by optical coherence tomography angiography were: choriocapillaris vessel density.

Time frame: 12 Months

Secondary Outcomes

Study of structural features of choroid in polypoidal choroidal vasculopathy after intravitreal

The effectiveness of Ranibizumab injections for treating PCV using optical optical coherence tomography. The parameters analyzed by optical coherence tomography were: subfoveal choroidal thickness.

Time frame: 12 Months

Data from ClinicalTrials.gov

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