INvestigating TELmisartin Study

Inclusion Criteria: * Able to provide written informed consent prior to initiation of any study procedures. * Within 72 hours of initial hospitalization for acute COVID-19 disease management * Male or non-pregnant female adult ≥18 years of age at time of enrolment. * Able to easily swallow pills Exclusion Criteria: * Systolic blood pressure less than 100 mmHg * Self-reported history of decompensated liver failure * Pregnancy or breast feeding * Allergy to the study medication * Current use of ARB, ACE inhibitors, or angiotensin receptor/neprilysin inhibitors (ARNIs). Blood pressure medications in other classes will be permitted as long as the systolic BP is \>100 mmHg * Currently receiving vasopressors for hypotension * Prior reaction or intolerance to ARB, ACE Inhibitor or ANRI for whom study participation would not be advisable in the opinion of the study team * Current use of and on-going need for aliskiren, lithium, digoxin, and potassium sparing diuretics such as spironolactone * Participating in other drug clinical trials EXCEPT for other COVID-19 treatment trials which will be allowed with the permission of the Corresponding PI or Co-PI and concurrence of the treating physician/hospitalist * Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \> 10x upper limit of normal (ULN) within 24 hours of baseline * Absolute neutrophil count (ANC) \< 1000/mL within 24 hours of baseline * Platelet count \< 50,000/mL within 24 hours of baseline. * Patients with acute kidney injury (AKI) or chronic kidney disease (CKD) including individuals on hemodialysis may be enrolled based on the investigator's clinical judgement. * Any serious medical condition/ abnormality or other issues that, in the investigator's judgment, precludes the patient's safe participation in and completion of the study or suggests that the study is not in the patient's best interest * In the opinion of the investigator, progression to death is imminent and inevitable within the next 24 hours, irrespective of the provision of treatments