Long Term Outcomes of Coronavirus Disease-19 (COVID-19)

Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital70 enrolled

Overview

The investigators hypothese that lung involvement due to COVID-19 may cause structural changes in the lung in the long term. In this study the effects of structural changes in the lung on pulmonary function tests, exercise capacity and quality of life will be examined.

Coronavirus disease-19 (COVID-19) has a clinical spectrum ranging from asymptomatic cases to severe cases requiring intensive care hospitalization due to respiratory failure. The disease mostly infects the lower respiratory tract. Typical computed tomography findings of lung involvement are bilateral, peripherally located ground glass density and consolidations. There is a close relationship between tomography findings and clinical severity. It is not known whether there will be complete recovery in the lungs. Investigators will evaluate pulmonary structures with chest computed tomography, respiratory capacity with pulmonary function tests (PFTs), exercise capacity with six minutes walk test and quality of life with short form-36 (SF-36) im patients who survivors of COVID-19 at least 6 months after hospital discharge.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Covid19

Interventions

Chest Computed TomographyDIAGNOSTIC_TEST

Evaluation of Lung Structure

Pulmonary Function TestsDIAGNOSTIC_TEST

Respiratory Capacity

Six Minutes Walk TestOTHER

Exercise Capacity

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who were ≥18 years * COVID-19 confirmed by Real-Time PCR * At least 6 months after discharge Exclusion Criteria: * Patients who were \< 18 years * Pregnancy * Become bedridden after discharge

Locations (1)

1University of Health Sciences Turkey, Dr Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Intensive Care Unit

Izmir, Turkey (Türkiye)

Outcomes

Primary Outcomes

Structural Change in Lung

Chest Computed Tomography

Time frame: up to 6 months after discharge

Secondary Outcomes

Carbon monoxide diffusion capacity (DLCO)

Carbon monoxide diffusion capacity of the lung

Time frame: up to 6 months after discharge

Exercise Capacity

Six Minutes Walking Test

Time frame: up to 6 months after discharge

Short Form Health Survey Score (SF-16)

A 36-item patient-reported questionnaire that covers eight health domains: physical functioning (10 items), bodily pain (2 items), role limitations due to physical health problems (4 items), role limitations due to personal or emotional problems (4 items), emotional well-being (5 items), social functioning (2 items), energy/fatigue (4 items), and general health perceptions (5 items). Scores for each domain range from 0 to 100, with a higher score defining a more favorable health state

Time frame: up to 6 months after discharge

Data from ClinicalTrials.gov

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