Neurodynamics of Prosocial Emotional Processing Following Serotonergic Stimulation With N,N-Dimethyltryptamine (DMT) and Harmine in Healthy Subjects

Inclusion Criteria: * Willing and capable to give informed consent for the participation in the study after it has been thoroughly explained * Little or no previous experiences with psychedelic substances * Body mass index (BMI) between 18.5 and 25 * Willing to refrain from drinking caffeine 3 days and alcohol the day before testing session, from drinking alcohol and caffeinated drinks at the testing days and from consuming psychoactive substances or other medications for 2 weeks before testing days and for the duration of the study * Able and willing to comply with all study requirements * Informed consent form was signed * Good knowledge of the German language Exclusion Criteria: * Previous significant adverse response to a hallucinogenic drug * Participation in another study where pharmaceutical compounds will be given * Self or first-degree relatives with present or antecedent psychiatric disorders * History of head trauma or fainting * Recent cardiac or brain surgery * Current use of medication or psychotropic substances (including nicotine addiction) * Presence of major internal or neurological disorders (including sepsis, pheochromocytoma, thyrotoxicosis, drug-induced fibrosis, familiar or basilar artery migraine) * Cardiovascular disease (hypertonia, coronary artery disease, heart insufficiency, myocardial infarction, coronary spastic angina) * Peripheral vascular disease (thromboangiitis obliterans, luetic arteritis, severe arteriosclerosis, thrombophlebitis, Raynaud's disease) * Liver or renal disease