Atrial myopathy is considered to be the underlying cause of a large proportion of embolic strokes of undetermined source. However, the definition of this atrial condition is not well delineated while its identification could lead to prescription on anticoagulation in order to avoid stroke recurences. This study aims to identify new markers of atrial myopathy and choosed a multi parametric approach with electrical, echographical, biological and 4D flow CMR derived markers.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
Acquisitions of MR imagining with special contrast phase CMR sequences. There is no need for agent contrast injection. The CMR is performed at the time of inclusion.
Collection of medical history, treatment, physical examination and realization of a 12 leads ECG.
48 hours ECG recording
Service d'urgences neuro-vasculaires, service de neurologie vasculaire Hôpital neurologique Pierre Wertheimer
Bron, France
NOT_YET_RECRUITINGService Imagerie médicale Hôpital neurologique Pierre Wertheimer
Bron, France
NOT_YET_RECRUITINGService rythmologie, Hôpital cardiologique Louis Pradel
Bron, France
RECRUITINGMean flow velocities in the left atrium
Velocity magnitude (cm/s) for all atrial voxels and all cardiac frames will be plotted in a histogram and normalized by the total number of voxels to allow comparisons between subjects
Time frame: One Day
Maximal flow velocities in the left atrium
Velocity magnitude (cm/s) for all atrial voxels and all cardiac frames will be plotted in a histogram and normalized by the total number of voxels to allow comparisons between subjects. Local peak velocity will be obtained by averaging 5 percent of all maximum values.
Time frame: One Day
Left atrium stasis
Velocity magnitude (cm/s) for all atrial voxels and all cardiac frames will be plotted in a histogram and normalized by the total number of voxels to allow comparisons between subjects. Local peak velocity will be obtained by averaging 5 percent of all maximum values
Time frame: One Day
Vortex size
Vortices in the isolated LA chamber were detectedusing the Lambda2 (λ2) method, which is an objective and widelyaccepted method to identify 3D vortice.
Time frame: One Day
Left atrium volume
Extracted from 3D MR reconstruction, expressed in mL/m2 of body surface area.
Time frame: One Day
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Trans thoracic echocardiography with standard measures performes in the core lab.
Blood sample in a peripheral vein, send to medical laboratory to dosage of NT pro BNP and troponin serum level.
Acquisitions of MR imagining