Intraosseous vs Submucosal Injection of Dexamethasone

Hams Hamed Abdelrahman38 enrolled

Overview

Thirty-eight patients were randomly divided into 2 groups; the intraosseous injection group of dexamethasone (4 mg) and the submucosal injection group. All surgeries were performed by one surgeon. Postoperative pain was evaluated by visual analog scale score immediately after surgery and on postoperative days 1, 3, and 7. Swelling (determined using two linear measurements) were assessed just before the surgery and on postoperative days 1, 3, and 7 by using a digital vernier caliper. Early healing of periodontal soft tissue wound was assessed by using Early Wound Healing Score (EHS) which composed of 3 parameters: clinical signs of re-epithelization (CSR), clinical signs of hemostasis (CSH), and clinical signs of inflammation (CSI) and were assessed on postoperative days 1, 7, and 14. Mouth opening (determined by measurement of the maximum inter-incisal distance) were assessed just before the surgery and on postoperative days 1, 3, and 7 by using a digital vernier caliper.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Tooth, Impacted

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion criteria * Patient complaining of impacted mandibular third molar mesioangular or horizontal, according to the Pell and Gregory classification 1933) * Healthy patient (American society of anesthesiologists class I status) * Patient age range from 18 to 40 years old. * Patient without any local inflammation or pathology. * Patient who will able to understand verbal and written instructions. Exclusion criteria * Pregnant or breast-feeding women. * Patient had anti-inflammatory drugs within 2 weeks before the procedure. * Patient under radiotherapy or chemotherapy. * Habits (heavy smoking and alcoholic). * Allergy to drugs used in this study. * Patient under anticoagulant or corticosteroid therapy.

Outcomes

Primary Outcomes

Change in mouth opening

determined by measurement of the maximum inter-incisal distance assessed by using a digital vernier caliper

Time frame: baseline, 1st, 3rd, 7th days

change in swelling

assessed by measuring two linear references (horizontal and vertical) with digital vernier caliper 1. Horizontal reference between the corner of the mouth and the tragus of the ear. 2. Vertical reference between the lateral canthus and the angle of the mandible.

Time frame: 1st, 3rd, 14th days

change in pain scores

Pain will be assessed by using a visual analog scale (VAS) (13) immediately after surgery and on postoperative days 1, 3, and 7.

Time frame: 1st, 3rd, 7th days

Secondary Outcomes

change in early healing of periodontal soft tissue wound

The EHS is composed of 3 parameters: 1. Clinical signs of re-epithelization (CSR). 2. Clinical signs of haemostasis (CSH). 3. Clinical signs of inflammation (CSI).

Time frame: 1st, 7th, 14th days