Blood Sample Collection for Experimental Blood Test to Track Liver Cancer

Inclusion Criteria: * Provide signed and dated informed consent form * Willing to comply with all study procedures and be available for the duration of the study * Definite diagnosis of hepatocellular carcinoma established (by standard radiographic or histologic criteria) * Felt to be reasonable candidate for liver transplantation, potentially contingent on success of down-staging therapy Exclusion Criteria: * Either active or recent solid organ cancer other than hepatocellur carcinoma (HCC) within the last 5 years, unless determined by transplant hepatology team not to represent contra-indication to liver transplantation * Contra-indication to LRT (as assessed by interventional radiologist, for example severe thrombocytopenia, severe vascular disease precluding access, etc) * History of prior liver transplantation * Active or prior systemic therapy for HCC