LUNA-EMG to Enhance Motor Functions in Multiple Sclerosis

N/ACompletedNCT04720898

University of Liege42 enrolled

Overview

The aim of the present study is to evaluate the effects of training performed with the LUNA-EMG system to enhance motor functions of the lower limb in multiple sclerosis. This is a randomized open-label trial. Patients will be randomized into the intervention group (LUNA-EMG, 30-45 minutes once a week for 12 weeks) or in the control group (standard care). The effect of the training will be measured based on the muscular strength, walking tests, proprioception and a quality of life questionnaire.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Multiple Sclerosis

Interventions

LUNA-EMGDEVICE

The LUNA-EMG (Samcom) system is a robot that allows the evaluation of muscular strength through the recording of muscle activity (electromyography - EMG) in order to provide precise objective data on the patient's muscle function. In addition to the diagnostic aspect (evaluation of muscle strength, range of motion and proprioception), the LUNA-EMG robot provides optimized range of motion's movements and a visual feedback on the patient's performance. In addition, it may enhance neuroplasticity due to the increased number of movements repetitions which could influence motor learning.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * EDSS less or equal to 6.5 * Between 18 and 70 years old * Having signed the informed consent Exclusion Criteria: * Acute pain syndrome * Severe cognitive deficits * Risk of fracture or unconsolidated fracture * Rigid joints (spasticity, severe osteoarthritis and arthritis) or unstable joints * Severe ataxia and apraxia * Epilepsy * Pacemakers and similar implants * Insufficient skin conditions

Locations (1)

CNRF

Tinlot, Liege, Belgium

Outcomes

Primary Outcomes

Muscle strength in mV

Muscular strength is measured with a dynamometer.

Time frame: 12 weeks

Secondary Outcomes

Timed 25-Foot Walk, seconds

The patient is directed to one end of a clearly marked 25-foot course and is instructed to walk 25 feet as quickly as possible, but safely. The faster the better.

Time frame: 12 weeks

Timed Up and Go, seconds

The person must get up from the seated position and walk three meters away from the chair and then retrace their steps (turn 180 degrees) and sit down again. The faster the better.

Time frame: 12 weeks

Proprioception

Patients proprioception will be measured with the LUNA system. It calculates the distance in degree (°) between the target arm position and the arm position that the patient try to reproduce. Lower degree represent a more accurate positioning of the arm by the patient.

Time frame: 12 weeks

Data from ClinicalTrials.gov

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