Trastuzumab-pkrb Combined With Modified FOLFOX-6 in Biliary Tract Cancer Patients Progressed on First Line Therapy

Inclusion Criteria: 1. Histologically documented recurred/metastatic/unresectable biliary tract cancer, including gallbladder cancer, intrahepatic, extrahepatic cholangiocarcinoma, or ampulla of vater cancer. 2. Histologically confirmed HER2 positive biliary tract cancer. HER2-positive tumor was defined as either IHC 3+ or IHC 2+ in combination with ISH +, or ERBB2 amplification (≥6 copies) by tumor tissue NGS. 3. Recurred/metastatic/unresectable biliary tract cancer patient whose disease progression was confirmed by imaging modality after gemcitabine+cisplatin containing 1st line palliative chemotherapy regimen. Previous lines should be one or two (immunotherapy monotherapy not counted). 4. be willing and able to provide written informed consent/assent for the trial 5. be at least 19 years of age on day of signing informed consent 6. have measurable disease based on RECIST (Response Evaluation Criteria In Solid Tumors) version 1.1 7. have a performance status of 0 or 1 on the ECOG (Eastern Cooperative Oncology Group) Performance Scale 8. demonstrate adequate organ function 9. No severe valvular or arrhythmic cardiac disease with LVEF ≥ 50% 10. female subject of childbearing potential should have a negative urine or serum pregnancy or be willing to use birth control Exclusion Criteria: 1. Previous treatment history of oxaliplatin containing chemotherapy, anti-HER2 targeting treatment (trastuzumab, neratinib, lapatinib, and etc) 2. has had a prior anti-cancer chemotherapy, targeted small molecule therapy, or radiotherapy within 2 weeks prior to study Day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to agents administered. 3. has a known additional malignancy that is progressing or requires active treatment within 3 years, except basal cell carcinoma of the skin, squamous cell carcinoma of the skin and thyroid cancer that has undergone potentially curative therapy or in situ cervical cancer 4. has known active central nervous system (CNS) metastases and/or carcinomatous meningitis 5. has known history or evidence of any disease, treatment, or laboratory results that would inhibit the patient's participation to the study. 6. Has clinically significant cardiac disease, including congestive heart failure ≥ NYHA grade 2, uncontrolled hypertension, QTcF \> 470 msec or QT prolong syndrome, recent myocardiac infarction or unstable angina history 7. has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial 8. is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through 120 days after the last dose of trial treatment 9. has a known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies) 10. has known active Hepatitis B (HBsAg reactive and HBV DNA 100 ≥copies/ml) or Hepatitis C (anti-HCV reactive and HCV RNA \[qualitative\] is detected) 11. has received a live vaccine within 30 days of planned start of study therapy. 12. has an active infection requiring systemic therapy 13. has history of severe adverse event or allergic reaction to 5-FU, leucovorin, oxaliplatin or trastuzumab 14. need O2 supply or show dyspnea on rest due to advanced malignancy