Nigella Sativa Oil Extract and Xenograft Bone Graft in Treatment of Infra-bony Defects

Tanta University10 enrolled

Overview

The aim of this study will be to evaluate, clinically, and radiographically the effect of Nigella Sativa oil extract Mixed with xenograft versus xenograft alone in the treatment of intra-bony defects in patients with aggressive periodontitis.

in 10 patients, twenty sites in subjects with, localized aggressive periodontitis, with CAL ≥ 5 will be included in the present study. Sites will be allocated randomly to be surgically treated with, Nigella Sativa oil extract Mixed with xenograft or xenograft alone. At baseline, 3, 6 after surgery, the following clinical parameters (PD, CAL, BOP) and CBCT at baseline and 6 months x-ray will be recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Localized Aggressive Periodontitis

Interventions

periodontal regenerative surgeryPROCEDURE

Procedure/Surgery: open flap debridement Open flap for removal of diseased periodontal tissues and necrotic cementum , using xenogenic bone graft with or without Nigella Sativa oil extract

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * systemically healthy patients were selected * patients who had not received any medications for the previous six months that may interfere with periodontal tissue health or healing. * Patients should demonstrate their ability to maintain good oral hygiene Exclusion Criteria: * • Smokers and pregnant patients. * Medically compromised patients and systemic conditions precluding periodontal surgery. * Subjects who do not comply with oral hygiene measures as evidenced in recall visits. * Restoration or caries in the site to be treated or non-vital tooth * Restoration or caries in the site to be treated or non-vital tooth

Locations (1)

Doaa Ahmed yousef bayoumi

Tanta, Gharbia Governorate, Egypt

Outcomes

Primary Outcomes

probing pocket depth

probing pocket depth probing pocket depth will be recorded at baseline, 3, and 6 months at the site to be treated

Time frame: 6 months

clinical attachment level

clinical attachment level will be recorded at baseline, 3, and 6 months at the site to be treated

Time frame: 6 months

bleeding on probing

bleeding on probing will be recorded at baseline, 3, and 6 months at the site to be treated

Time frame: 6 months

cone beam x ray measuring bone fill

bone fill will be recorded at baseline, and 6 months at the site to be treated

Time frame: 6 months

Data from ClinicalTrials.gov

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