ICU-Aw is highly prevalent (50%) among critically ill patients. Its diagnosis is usually delayed as it requires patients' awakening and collaboration to provide accurate measurement. This study aims to investigate the accuracy of an early ultrasound measurement of quadriceps shortening during neuromuscular electrical stimulation to diagnose future ICU-Aw in critically ill patients.
Study Type
OBSERVATIONAL
Enrollment
80
NMES will be applied to the quadriceps muscle to generate muscle contraction. Ultrasound measurement of the quadriceps thickness will be provided during contraction and rest, and the shortening of the quadriceps muscle will be measured. A second measurement using Shear-wave elastography measurement will also be undertaken. The measures will be undertaken at day 1 of neuromuscular blockers liberation (if any) as well as at day 3 and day 7 for the patients that will still be received mechanical ventilation at that time.
Groupe Hospitalier du Havre
Montivilliers, France
ICU-Aw diagnosis
Measured with the Medical Research Council score (scored 0 (minimum) to 60 (maximum); with a score \< 48 meaning ICU-acquired weakness)
Time frame: In the 24 hours following extubation
Respiratory muscles strength
Maximal Inspiratory Pressure and Maximal Expiratory Pressure
Time frame: In the 30 minutes before extubation (during spontaneous breathing trial)
Cough capacity
Peak Cough Flow
Time frame: In the 30 minutes before extubation (during spontaneous breathing trial)
Extubation failure/success
Reintubation or death
Time frame: Within 48 hours after extubation
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