Gestational diabetes is the most common complication during pregrancy. With a screening between week 24 and 28 of gestation women with gestational diabetes can be identified and treated. Treatment comprises modification of diet and in some cases taking medication. This treatment lowers undesirable events like macrosomia or premature birth. However, unitl gestational diabetes is diagnosed the fetus is exposed to increased intrauterine glucose levels. The long-term effects of a well-managed gestational diabetes on the development of the offspring is still not well understood. Therefore, the PREG - Offspring study investigates several aspects of development in children from healthy and gestational diabetes mothers until adulthood.
Study Type
OBSERVATIONAL
Enrollment
100
intrauterine exposure to elevated glucose levels
University Hospital Tübingen
Tübingen, Germany
RECRUITINGBody height
Body height is measured with a tape measure in centimeter (cm)
Time frame: Change in body height from birth to age 6, 10, 14 and 17
Body weight
Body weight is measured with a scale in kilogram (kg)
Time frame: Change in body weight from birth to age 6, 10, 14 and 17
Body fat
Body fat content is measured with bioimpedance anaylsis in percent (%)
Time frame: Change of body fat from age 6 to age 10, 14 and 17
Blood pressure
Blood pressure is measured with a blood pressure monitor as systolic and diastolic pressure in millimeter mercury column (mm Hg)
Time frame: Change of blood pressure from age 6 to age 10, 14 and 17
Pubertal development scale
Pubertal development scale is assessed according to Tanner stages
Time frame: Change of pubertal development scale from age 6 to age 10, 14 and 17
Blood glucose
Blood glucose is measured in blood sample in miligram per deciliter (mg/dl)
Time frame: Change of blood glucose from age 6 to age 10, 14 and 17
HbA1C
HbA1C is measured in blood sample in percent (%)
Time frame: Change of HbA1C from age 6 to age 10, 14 and 17
Cardiometabolic risk markers
Cholesterol, Low-density Lipoprotein, High-density Lipoprotein, Triglycerides, Lipoprotein(a) are measured in blood sample in mg/dl
Time frame: Change of cardiometabolic risk markers from age 6 to 10, 14 and 17
Continuous glucose monitoring
24h glucose profiles and postprandial glycemic excursions (AUC) will be measured by flash glucose monitoring
Time frame: Change of blood glucose from age 6 to age 10, 14 and 17
Activity level
Activity level is assessed with the MOMO activity questionnaire
Time frame: Change of activity level from age 6 to 10, 14 and 17
Magnetic resonance imaging
Distribution of whole body fat and visceral and subcutaneous fat confirmed by MR-Imaging and proton magnetic resonance spectroscopy by 3T Whole Body Imager
Time frame: Change of magnetic resonance images from age 6 to 10, 14 and 17
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